VERAPAMIL IMPURITY J
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- CAS号:
- 67018-85-3
- 英文名:
- NORVERAPAMIL
- 英文别名:
- D591;NORVERAPAMIL;Norverapamil D6;Verapamil Impurity J;Crufomate Impurity 3;Verapamil EP Impurity J Monomer;(2RS)-2-(3,4-Dimethoxy-phenyl)-5-[[;2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(3,4-dimethoxyphenethylamino)valeronitrile;5-[(3,4-dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile;α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-isopropylbenzeneacetonitrile
- 中文名:
- VERAPAMIL IMPURITY J
- 中文别名:
- 维拉帕米EP杂质J;化合物 T12244;化合物 NORVERAPAMIL;盐酸维拉帕米杂质J(EP) 标准品;维拉帕米杂质10 单体(维拉帕米EP杂质J 单体);维拉帕米杂质10 甲酸盐(维拉帕米EP杂质J 甲酸盐)
- CBNumber:
- CB0223348
- 分子式:
- C26H36N2O4
- 分子量:
- 440.58
- MOL File:
- 67018-85-3.mol
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VERAPAMIL IMPURITY J性质、用途与生产工艺
Norverapamil ((±)-Norverapamil)，是 Verapamil 的 N-去甲基代谢物，是一种钙通道 (L-type calcium channel) 阻滞剂和 P-糖蛋白 (P-gp) 功能抑制剂。
Calcium channel blocker
P-glycoprotein (P-gp) inhibitor
Norverapamil ((±)-Norverapamil) is similarly effective as verapamil at inhibiting isoniazid and rifampicin tolerance and killing of intracellular M. tuberculosis in the absence of other drugs. norverapamil, also inhibits macrophage-induced tolerance and achieves similar serum levels to verapamil.
Verapamil and its major metabolite Norverapamil were identified to be both mechanism-based inhibitors and substrates of CYP3A and reported to have non-linear pharmacokinetics in clinic.
Norverapamil (9 mg/kg; p.o.), a major metabolite of verapamil, has terminal half-life, AUC and Cmax values of 9.4 hours, 260 ng▪h/ml, and 41.6 ng/mL, respectively.
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Animal Model:
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Male Sprague-Dawley rats
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Dosage:
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9 mg/kg (Pharmacokinetic Study)
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Administration:
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Oral administration
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Result:
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t
1/2
=9.4 hours;
AUC=260 ng▪h/mL;
C
max
=41.6 ng/mL.
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VERAPAMIL IMPURITY J
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67018-85-3, VERAPAMIL IMPURITY J 相关搜索:
- 杂质对照品
- 抑制剂
- C26H36N2O4
- 化合物 NORVERAPAMIL
- 维拉帕米杂质10 甲酸盐(维拉帕米EP杂质J 甲酸盐)
- 维拉帕米杂质10 单体(维拉帕米EP杂质J 单体)
- 维拉帕米EP杂质J
- 化合物 T12244
- 盐酸维拉帕米杂质J(EP) 标准品
- 67018-85-3
- Crufomate Impurity 3
- Verapamil EP Impurity J Monomer
- Benzeneacetonitrile, α-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-(1-methylethyl)-
- (2RS)-2-(3,4-Dimethoxy-phenyl)-5-[[
- 5-[(3,4-dimethoxyphenethyl)amino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
- Norverapamil D6
- Verapamil Impurity J
- α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]propyl]-3,4-dimethoxy-α-isopropylbenzeneacetonitrile
- 2-(3,4-Dimethoxyphenyl)-2-isopropyl-5-(3,4-dimethoxyphenethylamino)valeronitrile
- D591
- Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)-ethyl]amino]propyl]-3,4-dimethoxy-a-(1-methylethyl)-
- NORVERAPAMIL