LIRIMILAST
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- CAS号:
- 329306-27-6
- 英文名:
- LIRIMILAST
- 英文别名:
- LIRIMILAST;BAY 19-8004;BAY 19-8004 - Lirimilast;2-(2,4-Dichlorobenzoyl)-3-ureidobenzofuran-6-yl methanesulfonate;Urea,[2-(2,4-dichlorobenzoyl)-6-[(methylsulfonyl)oxy]-3-benzofuranyl]-;UREA, N-[2-(2,4-DICHLOROBENZOYL)-6-[(METHYLSULFONYL)OXY]-3-BENZOFURANYL]-;METHANESULFONIC ACID 2-(2,4-DICHLORO-BENZOYL)-3-UREIDO-BENZOFURAN-6-YL ESTER
- 中文名:
- LIRIMILAST
- 中文别名:
- 化合物 T15766;2-(2,4-二氯苯甲酰基)-3-脲基苯并呋喃-6-基甲磺酸酯
- CBNumber:
- CB02451336
- 分子式:
- C17H12Cl2N2O6S
- 分子量:
- 443.26
- MOL File:
- 329306-27-6.mol
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LIRIMILAST化学性质
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沸点:
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663.2±55.0 °C(Predicted)
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密度:
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1.619±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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12.33±0.30(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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LIRIMILAST性质、用途与生产工艺
Lirimilast (BAY 19-8004) 是一种有效的,选择性的和口服活性的磷酸二酯酶 4 (PDE4) 抑制剂,IC50 值为 49 nM。Lirimilast 可用于哮喘或慢性阻塞性肺疾病 (COPD) 的研究,具有强效的抗炎特性。
In PDE4 assays Lirimilast (BAY 19-8004) is reported to be 5-fold more potent than Cilomilast and equipotent with CDP-840 using freshly prepared PDE4 from human PMNL.
Since Lirimilast (BAY 19-8004) is orally active in the guinea-pig at 3 mg/kg and, more critically, in primates at 0.1 mg/kg/day it appears to have a good therapeutic ratio. In addition Lirimilast is found to be 3-fold more potent than Cilomilast when compared in a rat model of lung neutrophilic inflammation.
LIRIMILAST
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-19672 | Lirimilast | | 1 mg | 2240元 |
2024/08/19 | HY-19672 | LIRIMILAST Lirimilast | 329306-27-6 | 5mg | 4480元 |
329306-27-6, LIRIMILAST 相关搜索:
- C17H12Cl2N2O6S
- 2-(2,4-二氯苯甲酰基)-3-脲基苯并呋喃-6-基甲磺酸酯
- 化合物 T15766
- 329306-27-6
- 2-(2,4-Dichlorobenzoyl)-3-ureidobenzofuran-6-yl methanesulfonate
- BAY 19-8004 - Lirimilast
- Urea,[2-(2,4-dichlorobenzoyl)-6-[(methylsulfonyl)oxy]-3-benzofuranyl]-
- UREA, N-[2-(2,4-DICHLOROBENZOYL)-6-[(METHYLSULFONYL)OXY]-3-BENZOFURANYL]-
- METHANESULFONIC ACID 2-(2,4-DICHLORO-BENZOYL)-3-UREIDO-BENZOFURAN-6-YL ESTER
- LIRIMILAST
- BAY 19-8004