网站主页 >> CAS数据库列表 >> (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE
(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE
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- CAS号:
- 204067-01-6
- 英文名:
- (S)-N-[[1-(5-METHOXY-2-PYRIDINYL)CYCLOHEXYL]METHYL]-A-METHYL-A-[[-(4-NITROPHENYL)AMINO]CARBONYL]AMINO-1H-INDOLE-3-PROPANAMIDE
- 英文别名:
- PD 176252;(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE;(S)-N-[[1-(5-METHOXY-2-PYRIDINYL)CYCLOHEXYL]METHYL]-A-METHYL-A-[[-(4-NITROPHENYL)AMINO]CARBONYL]AMINO-1H-INDOLE-3-PROPANAMIDE;(S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide;1H-Indole-3-propanamide, N-[[1-(5-methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-, (αS)-
- 中文名:
- (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE
- 中文别名:
- 化合物 T16449;(2S)-3-(1H-吲哚-3-基)-N-[1-(5-甲氧基吡啶-2-基)环己基]-2-甲基-2-[(4-硝基苯基)氨基甲酰氨基]丙酰胺
- CBNumber:
- CB02453426
- 分子式:
- C32H36N6O5
- 分子量:
- 584.67
- MOL File:
- 204067-01-6.mol
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(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE化学性质
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沸点:
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838.8±65.0 °C(Predicted)
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密度:
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1.297±0.06 g/cm3(Predicted)
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储存条件:
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Store at +4°C
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溶解度:
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Soluble to 100 mM in DMSO
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形态:
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Powder
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酸度系数(pKa):
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11.60±0.46(Predicted)
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颜色:
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Light yellow to yellow
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(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE性质、用途与生产工艺
PD176252 是一种有效的 BB1 和 BB2 拮抗剂,能够抑制人 BB1 和 BB2 受体和大鼠 BB1 和 BB2 受体活性,Ki 值分别为 0.17 nM,1 nM 和 0.66 nM,16 nM;PD176252 同时为 FPR1/FPR2 的激动剂,在 HL-60 细胞中,EC50 值分别为 0.31 和 0.66 μM。
Ki: 0.17 nM (Human BB
1
receptor), 0.66 nM (Rat BB
1
receptor), 1 nM (Human BB
2
receptor), 16 nM (Rat BB
2
receptor)
EC50: 0.31 μM (FPR1), 0.66 μM (FPR2)
PD176252 is a potent antagonist of neuromedin-B preferring (BB
1
) and gastrin-releasing peptide-preferring (BB
2
) receptor with K
i
s of 0.17 nM and 1 nM for human BB
1
and BB
2
receptors, and 0.66 nM, 16 nM for Rat BB
1
and BB
2
receptors, respectively. PD176252 inhibits acidification responses to neuromedin-B or neuromedin-C at the human BB
1
or BB
2
receptors expressed in CHO cells, with the appK
B
s of 4.0 nM or 13 nM, and blocks bombesin-evoked increases in intracellular calcium levels in CHO cells stably expressing human BB
1
or BB
2
receptors, with appK
B
s of 2.3 nM and 36 nM, respectively. PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC
50
s of 0.31 and 0.66 μM in HL-60 cells. PD176252 activates Ca
2+
mobilization in HL-60 cells transfected with human FPRs (EC
50
, 0.72 ± 0.21 μM). PD176252 inhibits little specific
125
I-gastrin releasing peptide binding to NCI-H345 cells at 1 nM and suppresses almost all specific bindings at 1000 nM, with an IC
50
of 30 nM. PD176252 (10, 30 μM) significantly inhibits the growth of NCI-H345 or H1299 cells, with IC
50
s of 7 and 5 μM.
PD176252 (1, 10 μg, p.o.) potently inhibits the growth of the proliferation of NCI-H1299 xenografts in nude mice.
(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
---|
2024/04/30 | HY-103286 | (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE PD176252 | 204067-01-6 | 5mg | 700元 |
2024/04/30 | HY-103286 | (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE PD176252 | 204067-01-6 | 10mM * 1mLin DMSO | 900元 |
(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE
生产厂家
204067-01-6, (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE 相关搜索:
- C32H36N6O5
- 化合物 T16449
- (2S)-3-(1H-吲哚-3-基)-N-[1-(5-甲氧基吡啶-2-基)环己基]-2-甲基-2-[(4-硝基苯基)氨基甲酰氨基]丙酰胺
- 204067-01-6
- 1H-Indole-3-propanamide, N-[[1-(5-methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-, (αS)-
- (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE
- (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide
- PD 176252
- (S)-N-[[1-(5-METHOXY-2-PYRIDINYL)CYCLOHEXYL]METHYL]-A-METHYL-A-[[-(4-NITROPHENYL)AMINO]CARBONYL]AMINO-1H-INDOLE-3-PROPANAMIDE