(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE

生物活性靶点体外研究体内研究 (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE 试剂级价格

CAS号:: 204067-01-6

英文名:: (S)-N-[[1-(5-METHOXY-2-PYRIDINYL)CYCLOHEXYL]METHYL]-A-METHYL-A-[[-(4-NITROPHENYL)AMINO]CARBONYL]AMINO-1H-INDOLE-3-PROPANAMIDE

英文别名:: PD 176252;(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE;(S)-N-[[1-(5-METHOXY-2-PYRIDINYL)CYCLOHEXYL]METHYL]-A-METHYL-A-[[-(4-NITROPHENYL)AMINO]CARBONYL]AMINO-1H-INDOLE-3-PROPANAMIDE;(S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide;1H-Indole-3-propanamide, N-[[1-(5-methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-, (αS)-

中文名:: (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE

中文别名:: 化合物 T16449;化合物PD176252;(2S)-3-(1H-吲哚-3-基)-N-[1-(5-甲氧基吡啶-2-基)环己基]-2-甲基-2-[(4-硝基苯基)氨基甲酰氨基]丙酰胺

CBNumber:: CB02453426

分子式:: C32H36N6O5

分子量:: 584.67

MOL File:: 204067-01-6.mol

化学性质安全信息用途价格供应商 26

(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE化学性质

沸点:: 838.8±65.0 °C(Predicted)

密度:: 1.297±0.06 g/cm3(Predicted)

储存条件:: Store at +4°C

溶解度:: Soluble to 100 mM in DMSO

形态:: Powder

酸度系数(pKa):: 11.60±0.46(Predicted)

颜色:: Light yellow to yellow

安全信息

(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE性质、用途与生产工艺

生物活性

PD176252 是一种有效的 BB1 和 BB2 拮抗剂，能够抑制人 BB1 和 BB2 受体和大鼠 BB1 和 BB2 受体活性，Ki 值分别为 0.17 nM，1 nM 和 0.66 nM，16 nM；PD176252 同时为 FPR1/FPR2 的激动剂，在 HL-60 细胞中，EC50 值分别为 0.31 和 0.66 μM。

靶点

Ki: 0.17 nM (Human BB ₁ receptor), 0.66 nM (Rat BB ₁ receptor), 1 nM (Human BB ₂ receptor), 16 nM (Rat BB ₂ receptor)
EC50: 0.31 μM (FPR1), 0.66 μM (FPR2)

PD176252 is a potent antagonist of neuromedin-B preferring (BB ₁ ) and gastrin-releasing peptide-preferring (BB ₂ ) receptor with K _i s of 0.17 nM and 1 nM for human BB ₁ and BB ₂ receptors, and 0.66 nM, 16 nM for Rat BB ₁ and BB ₂ receptors, respectively. PD176252 inhibits acidification responses to neuromedin-B or neuromedin-C at the human BB ₁ or BB ₂ receptors expressed in CHO cells, with the appK _B s of 4.0 nM or 13 nM, and blocks bombesin-evoked increases in intracellular calcium levels in CHO cells stably expressing human BB ₁ or BB ₂ receptors, with appK _B s of 2.3 nM and 36 nM, respectively. PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC ₅₀ s of 0.31 and 0.66 μM in HL-60 cells. PD176252 activates Ca ²⁺ mobilization in HL-60 cells transfected with human FPRs (EC ₅₀ , 0.72 ± 0.21 μM). PD176252 inhibits little specific ¹²⁵ I-gastrin releasing peptide binding to NCI-H345 cells at 1 nM and suppresses almost all specific bindings at 1000 nM, with an IC ₅₀ of 30 nM. PD176252 (10, 30 μM) significantly inhibits the growth of NCI-H345 or H1299 cells, with IC ₅₀ s of 7 and 5 μM.

体内研究

PD176252 (1, 10 μg, p.o.) potently inhibits the growth of the proliferation of NCI-H1299 xenografts in nude mice.

(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE 上下游产品信息

上游原料

下游产品

(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE 试剂级价格

更新日期	产品编号	产品名称	CAS编号	包装	价格
2024/04/30	HY-103286	(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE PD176252	204067-01-6	5mg	700元
2024/04/30	HY-103286	(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE PD176252	204067-01-6	10mM * 1mLin DMSO	900元

(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE 生产厂家

全球有 26家供应商 (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE国内生产厂家

供应商	联系电话	电子邮件	国家	产品数	优势度
武汉易泰科技有限公司上海分公司	821-50328103-801 18930552037	3bsc@sina.com	中国	15848	69
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	美国	8449	60
济南药研药物化学有限公司		jnyaoyan@163.com	中国	3069	58
南京美韬医药科技有限公司	meitaochem@126.com	meitaochem@126.com	中国	19105	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	美国	19892	58
BOC Sciences		info@bocsci.com	美国	0	65
天津普西唐生物医药科技有限公司	010-60605840 15801484223	psaitong@jm-bio.com	中国	29778	58
金瓯生物医药（南京）有限公司	13000000000	jinoupharma@163.com	中国	11732	58
开封明仁药业有限公司	0371-65741762	sales@hasunny.com	中国	2380	58
南通全益生物科技有限公司	0513-66337626 18051384581	sales@chemhifuture.com	中国	4455	58
TargetMol中国（陶术生物）	15002134094	marketing@targetmol.cn	中国	28118	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	美国	52927	58
ApexBio技术		sales@apexbt.com	美国	6254	58

204067-01-6, (2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE 相关搜索:

结晶磺胺 6-异丙基吡啶-3-醇

C32H36N6O5
化合物PD176252
化合物 T16449
(2S)-3-(1H-吲哚-3-基)-N-[1-(5-甲氧基吡啶-2-基)环己基]-2-甲基-2-[(4-硝基苯基)氨基甲酰氨基]丙酰胺
204067-01-6
1H-Indole-3-propanamide, N-[[1-(5-methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-, (αS)-
(2S)-3-(1H-INDOL-3-YL)-N-[[1-(5-METHOXYPYRIDIN-2-YL)CYCLOHEXYL]METHYL]-2-METHYL-2-[(4-NITROPHENYL)CARBAMOYLAMINO]PROPANAMIDE
(S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide
PD 176252
(S)-N-[[1-(5-METHOXY-2-PYRIDINYL)CYCLOHEXYL]METHYL]-A-METHYL-A-[[-(4-NITROPHENYL)AMINO]CARBONYL]AMINO-1H-INDOLE-3-PROPANAMIDE