N-ETHYLLIDOCAINE BROMIDE
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- CAS号:
- 24003-58-5
- 英文名:
- N-ETHYLLIDOCAINE BROMIDE
- 英文别名:
- N-ETHYLLIDOCAINE BROMIDE;QX 314 bromide,QX314 bromide;[2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide;2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE
- 中文名:
- N-ETHYLLIDOCAINE BROMIDE
- 中文别名:
- QX 314 溴化物;化合物 T16707
- CBNumber:
- CB02463601
- 分子式:
- C16H27BrN2O
- 分子量:
- 343.31
- MOL File:
- 24003-58-5.mol
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N-ETHYLLIDOCAINE BROMIDE化学性质
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熔点:
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214-215 °C
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储存条件:
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Desiccate at RT
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溶解度:
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insoluble in EtOH; ≥10.5 mg/mL in H2O; ≥25.55 mg/mL in DMSO
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形态:
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crystalline solid
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颜色:
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White
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水溶解性:
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Soluble to 100 mM in water
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N-ETHYLLIDOCAINE BROMIDE性质、用途与生产工艺
QX-314 bromide 是一种膜不渗透的钠离子通道永久性电荷阻滞剂。
QX-314 bromide exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels (TRPV1) in vitro .
QX-314 bromide (1–60 mM) directly activates TRPV1 in a concentration-dependent manner.
QX-314 bromide (≥ 30 mM) produces oocyte membrane blackening and cell death .
QX-314 bromide inhibits calcium currents in hippocampal CA1 pyramidal neurons intracellular, and the low-threshold (T-type) Ca
2+
currents are on average < 10% of control amplitude .
QX-314 bromide shifts the current-voltage relationships (I-Vs) in the positive voltage direction due to the presence of intracellular Br- .
QX-314 bromide (1.6 mg/kg; i.c.) abolishes responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
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Animal Model:
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Male Sprague-Dawley rats (250-290 g)
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Dosage:
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1.6 mg/kg
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Administration:
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Intracutaneous injection
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Result:
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Abolished responses to noxious mechanical and thermal stimuli without motor or tactile deficits when co-treatment with capsaicin.
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N-ETHYLLIDOCAINE BROMIDE
上下游产品信息
上游原料
下游产品
N-ETHYLLIDOCAINE BROMIDE
生产厂家
24003-58-5, N-ETHYLLIDOCAINE BROMIDE 相关搜索:
- 药靶配体
- QX 314 溴化物
- 化合物 T16707
- 24003-58-5
- QX 314 bromide,QX314 bromide
- [2-(2,6-dimethylanilino)-2-oxoethyl]-triethylazanium:bromide
- N-ETHYLLIDOCAINE BROMIDE
- 2-[(2,6-DIMETHYLPHENYL)AMINO]-N,N,N-TRIETHYL-2-OXO-ETHANAMINIUM BROMIDE