4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯
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- CAS号:
- 24136-23-0
- 英文名:
- 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
- 英文别名:
- MBX 102;JNJ 39659100;Arhalofenate;MBX-102 >=98% (HPLC);Rizatriptan Impurity 24;4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester;(aR)-4-Chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester;Benzeneaceticacid,4-chloro-α-[3-(trifluoromethyl)phenoxy]-,2-(acetylamino)ethylester,(αR)-;Benzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, 2-(acetylamino)ethyl ester, (αR)-;JNJ-39659100,MBX102,Arhalofenate,Inhibitor,MBX-102,inhibit,PPAR,Peroxisome proliferator-activated receptors,JNJ39659100
- 中文名:
- 4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯
- 中文别名:
- 芳卤芬酯;阿卤芬酯;化合物ARHALOFENATE;4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯
- CBNumber:
- CB02484831
- 分子式:
- C19H17ClF3NO4
- 分子量:
- 415.79
- MOL File:
- 24136-23-0.mol
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4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯化学性质
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沸点:
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551.1±50.0 °C(Predicted)
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密度:
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1.331
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储存条件:
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2-8°C
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溶解度:
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DMSO: ≥35mg/mL
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酸度系数(pKa):
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15.32±0.46(Predicted)
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形态:
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powder
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颜色:
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white to tan
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4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯性质、用途与生产工艺
Arhalofenate (MBX 102) 是选择性的(PPAR)-γ部分激动剂，常用于 2 型糖尿病的研究。
Arhalofenate (MBX 102) is a prodrug ester, that is rapidly and completely modified in vivo by non-specific serum esterases to the mature free acid form Arhalofenate (MBX 102) acid. Arhalofenate (MBX 102) shows a dose-dependent activation of mouse GAL4-PPAR-γ with EC
50
s of appr 12 μM.
Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly increases the glucose infusion rate and decreases hepatic glucose output in the clamped state in Zucker Diabetic Fatty (ZDF) rats. Arhalofenate (MBX 102) (60 mg/kg) leads to a dramatic decrease in plasma and also results in a dose-dependent, significant decrease in the insulin resistance indexinsulin levels. Arhalofenate (MBX 102) (100 mg/kg, p.o.) significantly decreases triglyceride, free fatty acid, and cholesterol levels in ZDF rats. MBX-102 significantly reduces fasting blood glucose, confirming that Arhalofenate (MBX 102) is an efficacious antidiabetic agent. Arhalofenate (MBX 102) (100 mg/kg, p.o.) also significantly lowers fasting plasma insulin, and robustly decreases fasting plasma triglycerides after 32 days of treatment in Zucker Fatty (ZF) rats.
4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-14831 | Arhalofenate | | 1 mg | 2210元 |
4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯
生产厂家
24136-23-0, 4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯 相关搜索:
- 抑制剂
- 阿卤芬酯
- 化合物ARHALOFENATE
- 芳卤芬酯
- 4-氯-ALPHA-[3-(三氟甲基)苯氧基]苯乙酸 2-(乙酰基氨基)乙酯
- 24136-23-0
- Rizatriptan Impurity 24
- JNJ-39659100,MBX102,Arhalofenate,Inhibitor,MBX-102,inhibit,PPAR,Peroxisome proliferator-activated receptors,JNJ39659100
- MBX-102 >=98% (HPLC)
- Benzeneaceticacid,4-chloro-α-[3-(trifluoromethyl)phenoxy]-,2-(acetylamino)ethylester,(αR)-
- Benzeneacetic acid, 4-chloro-α-[3-(trifluoromethyl)phenoxy]-, 2-(acetylamino)ethyl ester, (αR)-
- 4-Chloro-alpha-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
- (aR)-4-Chloro-a-[3-(trifluoromethyl)phenoxy]benzeneacetic acid 2-(acetylamino)ethyl ester
- JNJ 39659100
- Arhalofenate
- MBX 102