网站主页 >> CAS数据库列表 >> N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺
N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺
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- CAS号:
- 315703-52-7
- 英文名:
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- 英文别名:
- JK 184;CS-2369;JK184 (JK-184;Hh Signaling Antagonist VII;Hh Signaling Antagonist VII, JK184;JK 184;JK-184;HH SIGNALING ANTAGONIST VII;JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog;Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine;N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine
- 中文名:
- N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺
- 中文别名:
- 化合物JK184;JK184,刺猬信号抑制剂;HEDGEHOG(HH)抑制剂(JK184);N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺;N-(4-乙氧苯基)-4-(2-甲基咪唑并-[1,2-A]吡啶-3-基)噻唑-2-胺
- CBNumber:
- CB02485085
- 分子式:
- C19H18N4OS
- 分子量:
- 350.44
- MOL File:
- 315703-52-7.mol
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N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺化学性质
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储存条件:
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Keep in dark place,Inert atmosphere,2-8°C
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溶解度:
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DMSO: ≥20mg/mL
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形态:
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powder
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颜色:
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off-white to light brown
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N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺性质、用途与生产工艺
JK184抑制Hedgehog信号通路中的Gli,在哺乳动物细胞中IC50为30 nM。
JK184 is designed to antagonize Hh signaling by inhibiting glioma (Gli)-dependent transcriptional activity in a dose dependent manner. JK184 significantly inhibitts proliferation of HUVECs with IC
50
of 6.3 μg/mL after three days incubation. To evaluate anti-tumor effect of JK184, MTT assay is conducted in Panc-1 and BxPC-3 cells after administration with indicated concentrations of compounds, half maximal inhibitory concentration (IC
50
) of JK184 (23.7 ng/mL in anc-1 and 34.3 ng/mL in BxPC-3). Claudin-low cell lines are more sensitive to JK184 treatment than are MCF10a, MTSV1-7, or HMLE-shGFP and HMLE-pBP cells, and JK184 induced a dose-dependent decrease in glioma-associated oncogene homolog 1 (
GLI1
) transcript and protein levels in these cells. Treatment with the IC
50
dose of JK184 enhances the proportion of HMLE-shEcad cells that stained with Annexin-V, but are negative for propidium iodide (PI) (P<0.0001, t test).
JK184 (5 mg/kg, injected intravenously) exhibits good anti-proliferative activity in subcutaneous Panc-1 and BxPC-3 tumor models, and is a good candidate as antitumor drug targeted Hh signaling. However, JK184 has a poor pharmacokinetic profile and bioavailability.
N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-13307 | N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺 JK184 | 315703-52-7 | 5 mg | 450元 |
2024/08/19 | HY-13307 | N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺 JK184 | 315703-52-7 | 10mM * 1mLin DMSO | 495元 |
N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺
生产厂家
315703-52-7, N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺 相关搜索:
- 药靶配体
- 细胞生物学试剂
- JK184,刺猬信号抑制剂
- 化合物JK184
- HEDGEHOG(HH)抑制剂(JK184)
- N-(4-乙氧基苯基)-4-(2-甲基咪唑并[1,2-A]吡啶-3-基)噻唑-2-胺
- N-(4-乙氧苯基)-4-(2-甲基咪唑并-[1,2-A]吡啶-3-基)噻唑-2-胺
- 315703-52-7
- JK-184,inhibit,JK 184,JK184,Inhibitor,Hedgehog
- JK 184;JK-184;HH SIGNALING ANTAGONIST VII
- Hh Signaling Antagonist VII
- JK184 (JK-184
- CS-2369
- Hh Signaling Antagonist VII, JK184 - CAS 315703-52-7 - Calbiochem
- 2-ThiazolaMine, N-(4-ethoxyphenyl)-4-(2-MethyliMidazo[1,2-a]pyridin-3-yl)-
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine
- JK 184
- Hh Signaling Antagonist VII, JK184
- N-(4-Ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine