网站主页 >> CAS数据库列表 >> 2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮
2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮
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- CAS号:
- 1161233-85-7
- 英文名:
- BTZ043
- 英文别名:
- BTZ043;CS-2310;PBTZ 169;BTZ 10526043;BTZ043 raceMate;BTZ043 (BTZ-043;BTZ043;BTZ-043;BTZ 043;2-[(3S)-3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one;2-[(2S)-2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one;4H-1,3-Benzothiazin-4-one, 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-
- 中文名:
- 2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮
- 中文别名:
- 化合物BTZ043;DPRE1抑制剂(BTZ043);DPRE1抑制剂(PBTZ169);BTZ-043 CHIRALITY手性;2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮
- CBNumber:
- CB02512406
- 分子式:
- C17H16F3N3O5S
- 分子量:
- 431.39
- MOL File:
- 1161233-85-7.mol
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2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮化学性质
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熔点:
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190-191°C
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密度:
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1.68
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储存条件:
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-20°C Freezer
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溶解度:
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Chloroform (Slightly), Methanol (Very Slightly)
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形态:
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Solid
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颜色:
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White to Pale Yellow
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2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮性质、用途与生产工艺
BTZ043 是 DprE1 的抑制剂，它对结核分枝杆菌 H37Rv (M. tuberculosis H37Rv) 和耻垢分枝杆菌 (Mycobacterium smegmatis) 的 MIC 值分别为 2.3 nM 和 9.2 nM。
The MIC of BTZ043 against
M. tuberculosis H37Rv
and
Mycobacterium smegmatis
are 1 ng/mL (2.3 nM) and 4 ng/mL (9.2 nM), respectively. The in vitro activity of BTZ043 against 30
Nocardia brasiliensis
isolates is also tested. The MIC50 and MIC90 values for BTZ043 are 0.125 and 0.25 μg/mL. The MIC for
N. carnea
ATCC 6847 is 0.003μg/mL, for
N. transvalensis
ATCC 6865 is 0.003μg/mL, for N. brasiliensis NCTC10300 is 0.03 μg/mL, and for
N. brasiliensis
HUJEG-1 is 0.125μg/mL. The MIC value for
M. tuberculosis
H37Rv is 0.000976 μg/mL. The MIC value of BTZ-043 is >64 μg/mL for
Escherichia coli
ATCC 25922 and
S. aureus
ATCC 29213.
Four weeks of treatment with BTZ043 reduces the bacterial burden in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. Additional results suggest that BTZ043 efficacy is time-rather than dose-dependent. Acute (5 g/kg) and chronic (25 and 250 mg/kg) toxicology studies in uninfected mice show that, even at the highest dose tested, there are no adverse anatomical, behavioral, or physiological effects after one month.
2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-13579 | BTZ043 | | 1 mg | 500元 |
| 2024/04/30 | HY-13579 | 2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮
BTZ043 | 1161233-85-7 | 5mg | 1100元 |
2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮
生产厂家
1161233-85-7, 2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮 相关搜索:
- 细胞生物学试剂
- 抑制剂
- C17H16F3N3O5S
- BTZ-043 CHIRALITY手性
- 化合物BTZ043
- DPRE1抑制剂(PBTZ169)
- DPRE1抑制剂(BTZ043)
- 2-[(2S)-2-甲基-1,4-二氧杂-8-氮杂螺[4.5]癸烷-8-基]-8-硝基-6-三氟甲基-4H-1,3-苯并噻嗪-4-酮
- 1161233-85-7
- (S)-2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one
- 4H-1,3-Benzothiazin-4-one, 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-
- BTZ043;BTZ-043;BTZ 043
- CS-2310
- BTZ043 (BTZ-043
- 2-[(3S)-3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one
- PBTZ 169
- BTZ 10526043
- 2-[(2S)-2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one
- BTZ043 raceMate
- BTZ043