15-Lipoxygenase Inhibitor 1
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- CAS号:
- 928853-86-5
- 英文名:
- 15-Lipoxygenase Inhibitor 1
- 英文别名:
- 4-MMPB;15-Lipoxygenast Inhibitorl;15-Lipoxygenase Inhibitor I;15-Lipoxygenase Inhibitor 1;15-Lipoxygenase Inhibitor 1(4-MMPB);15-Lipoxygenase Inhibitor 1 Exclusive;4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine;5H-Pyrimido[4,5-b][1,4]benzothiazine, 4-methyl-2-(4-methyl-1-piperazinyl)-;LOX,4 MMPB,radical,Inhibitor,inhibit,4-MMPB,scavenging,Lipoxygenase,cancer,Apoptosis,4MMPB,inhibition
- 中文名:
- 15-Lipoxygenase Inhibitor 1
- 中文别名:
- 化合物15-LIPOXYGENASE INHIBITOR 1
- CBNumber:
- CB02589916
- 分子式:
- C16H19N5S
- 分子量:
- 313.42
- MOL File:
- 928853-86-5.mol
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15-Lipoxygenase Inhibitor 1化学性质
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沸点:
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532.1±60.0 °C(Predicted)
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密度:
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1.265±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Chloroform: >5mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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7.17±0.42(Predicted)
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颜色:
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Light yellow to orange
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15-Lipoxygenase Inhibitor 1性质、用途与生产工艺
4-MMPB 是一种选择性的脂氧合酶 15-lipoxygenase 抑制剂,其 IC50 值为 18 μM。4-MMPB 对大豆 15-脂氧合酶 (SLO) 和人 15-脂氧合酶-1 (15-LOX-1) 作用的 IC50 值分别为 19.5 μM 和 19.1 μM。4-MMPB 具有潜力用于前列腺癌的研究。
IC50: 18 μM (15-lipoxygenase)
4-MMPB has an IC
50
of 69.6 μM for DPPH bleaching.
4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.
4-MMPB (41.48 µM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
Cell Viability Assay
Cell Line:
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DU145 cells, PC-3 cells, HFF3 cells
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Concentration:
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9.57 µM, 19.94 µM, 39.88 µM, 79.77 µM,159.53 µM
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Incubation Time:
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24 hours, 48 hours, 72 hours
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Result:
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IC
50
s of 79.76 µM (24 hours), 51.05 µM (48 hours) and 41.48 µM (72 hours) for PC-3 cells, and 255.25 µM (24 hours), 130.81 µM (48 hours) and 98.91 µM (72 hours) for HFF3 cells.
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15-Lipoxygenase Inhibitor 1
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-118480 | 15-Lipoxygenase Inhibitor 1 4-MMPB | 928853-86-5 | 5mg | 2100元 |
2024/04/30 | HY-118480 | 15-Lipoxygenase Inhibitor 1 4-MMPB | 928853-86-5 | 10mM * 1mLin DMSO | 2310元 |
15-Lipoxygenase Inhibitor 1
生产厂家
928853-86-5, 15-Lipoxygenase Inhibitor 1 相关搜索:
- 药靶配体
- 抑制剂
- 化合物15-LIPOXYGENASE INHIBITOR 1
- 928853-86-5
- 5H-Pyrimido[4,5-b][1,4]benzothiazine, 4-methyl-2-(4-methyl-1-piperazinyl)-
- LOX,4 MMPB,radical,Inhibitor,inhibit,4-MMPB,scavenging,Lipoxygenase,cancer,Apoptosis,4MMPB,inhibition
- 15-Lipoxygenast Inhibitorl
- 4-MMPB
- 15-Lipoxygenase Inhibitor 1(4-MMPB)
- 4-methyl-2-(4-methylpiperazin-1-yl)-5H-pyrimido[4,5-b][1,4]benzothiazine
- 15-Lipoxygenase Inhibitor 1 Exclusive
- 15-Lipoxygenase Inhibitor I
- 15-Lipoxygenase Inhibitor 1