CS-2863
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- CAS号:
- 1018675-35-8
- 英文名:
- CVT-12012
- 英文别名:
- CS-2863;CVT-2012;CVT-12012;CVT 12012,Stearoyl-CoA Desaturase (SCD),inhibit,CVT12012,Inhibitor,CVT-12012;2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide;2-Hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]acetamide;Acetamide, 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-;2-Hydroxy-N-(2-(3-methyl-2-oxo-7-(((3-(trifluoromethyl)phenyl)methyl)amino)-1,2-dihydroquinoxalin-1-yl)ethyl)acetamide
- 中文名:
- CS-2863
- 中文别名:
- 化合物CVT-12012
- CBNumber:
- CB02627711
- 分子式:
- C21H21F3N4O3
- 分子量:
- 434.41
- MOL File:
- 1018675-35-8.mol
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CS-2863化学性质
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密度:
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1.37±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml; Ethanol: 1 mg/ml
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形态:
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A crystalline solid
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酸度系数(pKa):
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13.29±0.10(Predicted)
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颜色:
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Light yellow to yellow
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CS-2863性质、用途与生产工艺
CVT-12012 是一种有效的、具有口服活性的硬脂酰-CoA 去饱和酶 (SCD) 的抑制剂，其对大鼠微粒体和人 HEPG2 的 IC50 值分别为 38 nM，6.1 nM。
IC50: 38 nM (rat microsomal), 6.1 nM (human HEPG2).
CVT-12012 (Compound 5b) displays the highest potency in both the microsomal and the HEPG2 SCD assays (IC
50
38 nM and 6.1 nM, respectively) compared to the other methyl-substituted compounds.
In a rat PK study, CVT-12012 demonstrates good oral bioavailability (78%). It appears that the oral absorption of CVT-12012 is not affected by a significant Pgp efflux, which is expected based on Caco-2 assay result. The plasma clearance of CVT-12012 is high (88 mL/min/kg) with elimination half-life of approximately 1 h.
CS-2863
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-11034 | CVT-12012 | | 1 mg | 400元 |
| 2024/04/30 | HY-11034 | CS-2863
CVT-12012 | 1018675-35-8 | 5mg | 1000元 |
1018675-35-8, CS-2863 相关搜索:
- API
- 化合物CVT-12012
- 1018675-35-8
- CVT 12012,Stearoyl-CoA Desaturase (SCD),inhibit,CVT12012,Inhibitor,CVT-12012
- 2-Hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]acetamide
- Acetamide, 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-
- 2-Hydroxy-N-(2-(3-methyl-2-oxo-7-(((3-(trifluoromethyl)phenyl)methyl)amino)-1,2-dihydroquinoxalin-1-yl)ethyl)acetamide
- CS-2863
- CVT-2012
- 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide
- CVT-12012