NS-6180
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- CAS号:
- 353262-04-1
- 英文名:
- NS-6180
- 英文别名:
- NS6180;NS 6180;CS-1648;NS-6180;NS6180 >=98% (HPLC);NS6180;NS-6180;NS 6180;4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one;2H-1,4-Benzothiazin-3(4H)-one, 4-[[3-(trifluoromethyl)phenyl]methyl]-
- 中文名:
- NS-6180
- 中文别名:
- 化合物NS6180;化合物MERICITABINE;NS 6180,KCA3.1(IK)通道阻止器;4-[[3-(三氟甲基)苯基]甲基]-2H-1,4-苯并噻嗪-3(4H)-酮
- CBNumber:
- CB02667182
- 分子式:
- C16H12F3NOS
- 分子量:
- 323.33
- MOL File:
- 353262-04-1.mol
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NS-6180化学性质
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沸点:
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476.9±45.0 °C(Predicted)
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密度:
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1.375±0.06 g/cm3(Predicted)
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储存条件:
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Sealed in dry,2-8°C
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溶解度:
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DMSO: soluble20mg/mL, clear
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酸度系数(pKa):
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0.53±0.20(Predicted)
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形态:
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powder
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颜色:
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white to beige
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NS-6180性质、用途与生产工艺
NS6180是KCa3.1离子通道高效选择性抑制剂，IC50值9nM，阻止T细胞活化和炎症反应。
NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation. IC50 value: 9 nM [1] Target: KCa3.1 channel inhibitor in vitro: NS6180 inhibited cloned human KCa3.1 channels (IC50 = 9 nM) via T250 and V275, the same amino acid residues conferring sensitivity to triarylmethanes such as like TRAM-34. NS6180 inhibited endogenously expressed KCa3.1 channels in human, mouse and rat erythrocytes, with similar potencies (15–20 nM). NS6180 suppressed rat and mouse splenocyte proliferation at submicrolar concentrations and potently inhibited IL-2 and IFN-γ production, while exerting smaller effects on IL-4 and TNF-α and no effect on IL-17 production [1]. in vivo: DNBS challenged rats were treated with two doses (3 and 10 mg·kg-1 b.i.d.) of NS6180 for 7 days in direct comparison with the IBD drug sulfasalazine (300 mg·kg-1 q.d.). Both doses of NS6180 significantly improved weight gain and decreased inflammation induced swelling of the colon as determined by relative colon weight.
NS6180是KCa3.1离子通道高效选择性抑制剂，IC50值9nM，阻止T细胞活化和炎症反应。
NS-6180
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-15707 | NS-6180
NS6180 | 353262-04-1 | 5mg | 650元 |
| 2024/04/30 | HY-15707 | NS-6180
NS6180 | 353262-04-1 | 10mM * 1mLin DMSO | 715元 |
353262-04-1, NS-6180 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 小分子抑制剂
- 小分子抑制剂，天然产物
- NS 6180,KCA3.1(IK)通道阻止器
- 化合物MERICITABINE
- 化合物NS6180
- 4-[[3-(三氟甲基)苯基]甲基]-2H-1,4-苯并噻嗪-3(4H)-酮
- 353262-04-1
- NS6180 >=98% (HPLC)
- 2H-1,4-Benzothiazin-3(4H)-one, 4-[[3-(trifluoromethyl)phenyl]methyl]-
- CS-1648
- NS6180;NS-6180;NS 6180
- 4-[[3-(Trifluoromethyl)phenyl]methyl]-2H-1,4-benzothiazin-3(4H)-one
- NS-6180
- NS6180
- NS 6180