1177501-39-1
|
|
- CAS号:
- 1177501-39-1
- 英文名:
- FelbaMate (hydrate)
- 英文别名:
- FelbaMate (hydrate)
- 中文名:
- 1177501-39-1
- 中文别名:
- 非尔氨酯水合物;化合物 T22778
- CBNumber:
- CB02681999
- 分子式:
- C11H16N2O5
- 分子量:
- 256.26
- MOL File:
- 1177501-39-1.mol
|
|
|
1177501-39-1化学性质
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
形态:
-
Powder
-
|
1177501-39-1性质、用途与生产工艺
Felbamate hydrate (W-554 hydrate) 是非镇静性抗痉挛剂,活性与NMDA受体相关。
Felbamate hydrate (W-554 hydrate) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy. Felbamate (W-554) has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptor of relevance of NMDA receptor blockade as a strategy for the treatment of human epilepsy has been questioned. Therefore, the importance of the effects of felbamate on NMDA receptors to its therapeutic action in epilepsy is uncertain.
1177501-39-1
上下游产品信息
上游原料
下游产品
1177501-39-1, 1177501-39-1 相关搜索:
- 化合物 T22778
- 非尔氨酯水合物
- 1177501-39-1
- FelbaMate (hydrate)