NBI-31772 hydrate
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- CAS号:
- 374620-70-9
- 英文名:
- NBI-31772 hydrate
- 英文别名:
- NBI-31772 hydrate;NBI31772|||NBI 31772;NBI-31772 - CAS 374620-70-9 - Calbiochem;inhibit,IGF-responsive diseases,IGF-1R,IGFBP,NBI-31772,Inhibitor;1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid;3-Isoquinolinecarboxylic acid, 1-(3,4-dihydroxybenzoyl)-6,7-dihydroxy-
- 中文名:
- NBI-31772 hydrate
- 中文别名:
- 化合物NBI-31772;化合物 NBI-31772 HYDRATE;NBI 31772,胰岛素样生长因子-I结合蛋白IGFBP抑制剂
- CBNumber:
- CB02750422
- 分子式:
- C17H11NO7
- 分子量:
- 341.27
- MOL File:
- 374620-70-9.mol
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NBI-31772 hydrate化学性质
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沸点:
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764.7±60.0 °C(Predicted)
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密度:
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1.696±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 0.14 mg/ml
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酸度系数(pKa):
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6.68±0.20(Predicted)
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形态:
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Greenish-yellow solid
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颜色:
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Light yellow to brown
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NBI-31772 hydrate性质、用途与生产工艺
NBI-31772 hydrate 是胰岛素样生长因子 IGF 与 IGFBP 相互作用的有效抑制剂。NBI-31772 hydrate 也是一种非肽类配体，可从其结合蛋白复合物 IGF-I/IGFBP-3 中释放生物活性 IGF-I (对六种人类亚型的 Ki=1-24 nM) 。具有抗焦虑和抗抑郁作用。
NBI-31772 (5-100 μg; icv; immediately or at 1, 2, or, 3 hours after MCAO) at the time of ischemia onset also dose-dependently reduced infarct size, and the highest dose (100 μg) significantly reduced both total and cortical infarct volume.
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Animal Model:
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Sprague-Dawley rats (subtemporal middle cerebral artery occlusion model, MCAO)
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Dosage:
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5-100 μg
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Administration:
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Icv; immediately or at 1, 2, or, 3 hours after MCAO
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Result:
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Resulted in a significant reduction of the total and cortical lesion volume.
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NBI-31772 hydrate
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-110135A | NBI-31772 hydrate
NBI-31772 hydrate | 374620-70-9 | 5mg | 1500元 |
| 2024/11/08 | HY-110135A | NBI-31772 hydrate | | 10 mg | 2400元 |
374620-70-9, NBI-31772 hydrate 相关搜索:
- 抑制剂
- 标准品
- 药靶配体
- NBI 31772,胰岛素样生长因子-I结合蛋白IGFBP抑制剂
- 化合物 NBI-31772 HYDRATE
- 化合物NBI-31772
- 374620-70-9
- NBI31772|||NBI 31772
- 3-Isoquinolinecarboxylic acid, 1-(3,4-dihydroxybenzoyl)-6,7-dihydroxy-
- inhibit,IGF-responsive diseases,IGF-1R,IGFBP,NBI-31772,Inhibitor
- NBI-31772 - CAS 374620-70-9 - Calbiochem
- 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid
- NBI-31772 hydrate