化合物 T23819
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- CAS号:
- 1177798-88-7
- 英文名:
- N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride
- 英文别名:
- BRACO19 hydrochloride;BRACO19 HCl;BRACO-19
(BRACO19);BRACO19 trihydrochloride;N,N-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide Trihydrochlori;N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride;N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride
- 中文名:
- 化合物 T23819
- 中文别名:
- 化合物 T23819;三盐酸BRACO-19;BRACO19 3HCL;N,N'-[9[[4-(二甲氨基)苯基]氨基]-3,6-吖啶二基]双(1-吡咯烷丙酰胺)三盐酸盐
- CBNumber:
- CB02751065
- 分子式:
- C35H44ClN7O2
- 分子量:
- 630.23
- MOL File:
- 1177798-88-7.mol
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化合物 T23819化学性质
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储存条件:
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2-8°C
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溶解度:
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H2O: soluble5mg/mL, clear
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形态:
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powder
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颜色:
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yellow to brown
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化合物 T23819性质、用途与生产工艺
Braco-19 trihydrochloride 是一种有效的端粒酶/端粒 (telomerase/telomere) 抑制剂，可防止端粒酶的催化作用。Braco-19 trihydrochloride 作为四联体 (GQ) 结合配体，稳定 GQ 四联体在 3V 端粒 DNA 处的形成，并可以导致快速衰老或选择性细胞死亡。Braco-19 trihydrochloride 也是一种HAdV病毒复制抑制剂。
Braco-19 trihydrochloride, as a well-known GQ binding ligand, interacts specifically with the HAdV GQs and increases their stability, and blocks the HAdV multiplication.BRACO-19 trihydrochloride (1.0-10 μM; 5 day) cause zero growth inhibition is found 1 μM, the IC
50
for BRACO-19 in UXF1138L cells is 2.5 μM, the IC
100
is 5 μM.BRACO-19 trihydrochloride (1 μM; 24 hours) shows dramatically reduced nuclear hTERT expression. However, residual cytoplasmic hTERT staining is observed accompanied by the occurrence of atypical mitoses.BRACO-19 trihydrochloride (0-40 μM; 24 hours) decreases the AdV virus growth in a dose-dependent manner in eGFP-transinfected HEK 293 cells.BRACO-19 trihydrochloride (0-150 μM; 24 hours) shows a decrease in band intensity in an increasing concentration-dependent manner.
Cell Viability Assay
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Cell Line:
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HEK 293 cells
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Concentration:
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20 μM; 40 μM
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Incubation Time:
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24 hours
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Result:
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Displayed low cytotoxicity and decreased the eGFP fluorescence.
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BRACO-19 trihydrochloride (oral administration or intraperitoneal injection; 2 or 5 mg/kg; 3 weeks) oral dosing regimen are always inactive and the animals have to be sacrificed due to high tumor burden before overall termination of the study, Chronic, i.p. BRACO-19 administration, qdx5 is efficient in inhibiting tumor growth in earlystage xenografts but not advanced-stage xenografts. BRACO-19 trihydrochloride (intraperitoneal injection; 2 mg/kg; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments) inhibits tumor growth significantly and under these conditions, marked single-agent antitumor activity is observed, with some animals in the group showing complete regressions (5 of 12 tumors).
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Animal Model:
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Established UXF1138LX Xenografts in nude mice
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Dosage:
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2 mg/kg
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Administration:
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Intraperitoneal injection; 3 weeks; starting 6 days after transplantation of UXF1138LX fragments
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Result:
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Showed partial tumor regressions with an optimal T/C on day 28 of 4.1%, equal to 95.9% inhibition of tumor growth compared with control.
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化合物 T23819
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-15523A | Braco-19 trihydrochloride | | 10 mg | 2300元 |
| 2024/04/30 | HY-15523A | Braco-19 trihydrochloride | | 25 mg | 5000元 |
1177798-88-7, 化合物 T23819 相关搜索:
- BRACO19 3HCL
- 三盐酸BRACO-19
- N,N'-[9[[4-(二甲氨基)苯基]氨基]-3,6-吖啶二基]双(1-吡咯烷丙酰胺)三盐酸盐
- 化合物 T23819
- 1177798-88-7
- BRACO19 hydrochloride
- BRACO19 HCl
- N,N-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide Trihydrochlori
- BRACO-19
(BRACO19)
- N,N'-[9[[4-(Dimethylamino)phenyl]amino]-3,6-acridinediyl]bis-1-pyrrolidinepropanamide trihydrochloride
- BRACO19 trihydrochloride
- N,N′-(9-(4-(Dimethylamino)phenylamino)acridine-3,6-diyl)bis(3-(pyrrolidin-1-yl)propanamide) trihydrochloride