EB47; EB-47
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- CAS号:
- 1190332-25-2
- 英文名:
- EB 47
- 英文别名:
- EB47; EB-47;EB 47 (hydrochloride);EB 47, PARP-1 inhibitor;EB47 dihydrochloride,EB 47 dihydrochloride
- 中文名:
- EB47; EB-47
- 中文别名:
- 化合物 T22756;5′-脱氧-5′-[4-[2-[(2,3-二氢-1-氧代-1H-异吲哚-4-基)氨基]-2-氧代乙基]-1-哌嗪基]-5′-氧代腺苷二盐酸盐
- CBNumber:
- CB03037250
- 分子式:
- C24H28ClN9O6
- 分子量:
- 574
- MOL File:
- 1190332-25-2.mol
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EB47; EB-47化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 50 mg/ml, sonicated
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形态:
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A solid
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颜色:
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White to off-white
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EB47; EB-47性质、用途与生产工艺
EB-47 dihydrochloride 是一种有效的 PARP-1/ARTD-1 选择性抑制剂，IC50 值为 45 nM，对 ARTD5 的IC50 值为 410 nM，表现出温和的效果。EB-47 模拟底物 NAD+，从烟酰胺延伸至腺苷亚区结合。
EB-47 dihydrochloride shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC
50
values of 0.86 and 1.0 µM, respectively.
EB-47 dihydrochloride (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation.
EB47; EB-47
上下游产品信息
上游原料
下游产品
1190332-25-2, EB47; EB-47 相关搜索:
- C24H27N9O62HCl
- 5′-脱氧-5′-[4-[2-[(2,3-二氢-1-氧代-1H-异吲哚-4-基)氨基]-2-氧代乙基]-1-哌嗪基]-5′-氧代腺苷二盐酸盐
- 化合物 T22756
- 1190332-25-2
- EB 47, PARP-1 inhibitor
- EB 47 (hydrochloride)
- EB47 dihydrochloride,EB 47 dihydrochloride
- EB47; EB-47