2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚
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- CAS号:
- 1627710-50-2
- 英文名:
- 1627710-50-2
- 英文别名:
- LJH685;CS-2182;LJH685(LJH-685);LJH-685;LJH 685;LJH685;2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol;Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-;LJH685,S6K,LJH-685,Apoptosis,inhibit,Ribosomal S6 Kinase (RSK),LJH 685,Inhibitor
- 中文名:
- 2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚
- 中文别名:
- 化合物LJH685;RSK抑制剂(LJH685);2,6-二氟-4-(4-(4-(4-甲基哌嗪-1-基)苯基)吡啶-3-基)苯酚;2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚
- CBNumber:
- CB03060937
- 分子式:
- C22H21F2N3O
- 分子量:
- 381.42
- MOL File:
- 1627710-50-2.mol
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2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚化学性质
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沸点:
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481.1±45.0 °C(Predicted)
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密度:
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1.257±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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crystalline solid
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酸度系数(pKa):
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5.86±0.25(Predicted)
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颜色:
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White to off-white
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2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚性质、用途与生产工艺
LJH685 是一种有效的选择性,ATP-竞争性的 RSK 抑制剂, 抑制 RSK1/2/3 生物活性, IC50 为 6、5、4 nM。
IC50: 6 nM (RSK1), 5 nM (RSK1), 4 nM (RSK1)
LJH685 (0.01-100 μM; 72 hours) efficiently inhibits the growth of MDA-MB-231 and H358 cells in soft agar with EC
50
s of 0.73 and 0.79 μM, respectively.
LJH685 (0.1-10 μM; 4 hours) efficiently reduces phosphorylation of YB1 at submicromolar concentrations and causes nearly complete inhibition at higher concentrations.
Cell Proliferation Assay
Cell Line:
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MDA-MB-231, H358 cells
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Concentration:
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0.01, 0.1, 1, 10, 100 μM
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Incubation Time:
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72 hours
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Result:
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The growth in soft agar was efficiently inhibited with EC
50
values of 0.73 and 0.79 μM in MDA-MB-231 and H358, respectively.
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Western Blot Analysis
Cell Line:
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MDA-MB-231, H358 cells
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Concentration:
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0.1, 0.3, 1, 3, 10 μM
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Incubation Time:
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4 hours
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Result:
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Efficiently reduced phosphorylation of YB1 at submicromolar concentrations and caused nearly complete inhibition at higher concentrations.
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2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-19712 | LJH685 | | 1 mg | 431元 |
2024/04/30 | HY-19712 | 2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚 LJH685 | 1627710-50-2 | 5mg | 800元 |
2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚
生产厂家
1627710-50-2, 2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚 相关搜索:
- 药靶配体
- 细胞生物学试剂
- 抑制剂
- C22H21F2N3O
- 2,6-二氟-4-(4-(4-(4-甲基哌嗪-1-基)苯基)吡啶-3-基)苯酚
- 化合物LJH685
- RSK抑制剂(LJH685)
- 2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚
- 1627710-50-2
- LJH685,S6K,LJH-685,Apoptosis,inhibit,Ribosomal S6 Kinase (RSK),LJH 685,Inhibitor
- 2,6-Difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]phenol
- LJH685(LJH-685)
- LJH-685;LJH 685;LJH685
- CS-2182
- Phenol, 2,6-difluoro-4-[4-[4-(4-methyl-1-piperazinyl)phenyl]-3-pyridinyl]-
- LJH685