36840-10-5
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- CAS号:
- 36840-10-5
- 英文名:
- 4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)
- 英文别名:
- LPA2 antagonist 2,LPA-2 antagonist 2;4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid);4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid);4,4-(4,4-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)(WX610172);2-Butenoic acid, 4,4'-([1,1'-biphenyl]-4,4'-diyldiimino)bis[4-oxo-;(E)-4-[4-[4-[[(E)-3-carboxyprop-2-enoyl]amino]phenyl]anilino]-4-oxobut-2-enoic acid
- 中文名:
- 36840-10-5
- 中文别名:
- LPA2 拮抗剂 2;化合物 T11875;(2E,2E)-4,4-([1,1-二联苯]-4,4-叉基二(氨叉基))二(4-氧亚基丁-2-烯酸)
- CBNumber:
- CB03172261
- 分子式:
- C20H16N2O6
- 分子量:
- 380.35
- MOL File:
- 36840-10-5.mol
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36840-10-5化学性质
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沸点:
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758.0±60.0 °C(Predicted)
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密度:
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1.444±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 83.33 mg/mL (219.09 mM)
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酸度系数(pKa):
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3.16±0.10(Predicted)
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形态:
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Solid
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颜色:
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Light yellow to yellow
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36840-10-5性质、用途与生产工艺
LPA2 antagonist 2 是一种选择性 LPA2 拮抗剂,IC50 为 28.3 nM,Ki 为 21.1 nM,比 LPA3 (IC50 为 13.85 μM) 选择性高 480 倍以上。
IC50: 28.3 nM (LPA
2
); 13.85 μM (LPA
3
)
Lysophosphatidic acid (LPA) is a phospholipid mediator that elicits a host of biological effects including cell proliferation, survival, motility and differentiation. LPA has been shown to regulate cancer cell invasion, metastasis, and resistance to both chemotherapeutics and radiation. LPA2 antagonist 2 (H2L 5226501) inhibits LPA
1
with an Imax of 59.0% at 30 µM.
36840-10-5
上下游产品信息
上游原料
下游产品
36840-10-5, 36840-10-5 相关搜索:
- 抑制剂
- LPA2 拮抗剂 2
- 化合物 T11875
- (2E,2E)-4,4-([1,1-二联苯]-4,4-叉基二(氨叉基))二(4-氧亚基丁-2-烯酸)
- 36840-10-5
- 4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)
- LPA2 antagonist 2,LPA-2 antagonist 2
- (E)-4-[4-[4-[[(E)-3-carboxyprop-2-enoyl]amino]phenyl]anilino]-4-oxobut-2-enoic acid
- 2-Butenoic acid, 4,4'-([1,1'-biphenyl]-4,4'-diyldiimino)bis[4-oxo-
- 4,4-(4,4-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)(WX610172)
- 4,4'-(4,4'-Biphenyldiyldiimino)Bis(4-Oxo-2-Butenoic Acid)