FUDAEUIGIJZUAY-UMIRZPQISA-N
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- CAS号:
- 186371-96-0
- 英文名:
- FUDAEUIGIJZUAY-UMIRZPQISA-N
- 英文别名:
- ZK168281;ZK-168281,ZK168281;FUDAEUIGIJZUAY-UMIRZPQISA-N;2-Propenoic acid, 3-[1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]cyclopropyl]-, ethyl ester, (2E)-
- 中文名:
- FUDAEUIGIJZUAY-UMIRZPQISA-N
- 中文别名:
- 化合物 T13404
- CBNumber:
- CB03566499
- 分子式:
- C32H46O5
- 分子量:
- 510.7
- MOL File:
- 186371-96-0.mol
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FUDAEUIGIJZUAY-UMIRZPQISA-N化学性质
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沸点:
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652.9±55.0 °C(Predicted)
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密度:
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1.15±0.1 g/cm3(Predicted)
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储存条件:
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4°C, protect from light, stored under nitrogen
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酸度系数(pKa):
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14.29±0.20(Predicted)
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形态:
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Solid
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颜色:
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White to off-white
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FUDAEUIGIJZUAY-UMIRZPQISA-N性质、用途与生产工艺
ZK168281 是一种 1α,25(OH)2D3 类似物，也是一种纯 VDR 拮抗剂，Kd 值为 0.1 nM。ZK168281 是其受体 CoA 相互作用的有效抑制剂。
ZK168281 resembles more the mouse constitutive androstane receptor (CAR) inverse agonist Androstanol in its ability to recruit corepressor (CoR) proteins. A salt bridge between the CoR and a conserved lysine in helix 4 of the nuclear receptor (NR) is central to this interaction, but also helix 12 was stabilized by direct contacts with residues of the CoR. Fixation of helix 12 in the antagonistic/inverse agonistic conformation prevents an energetically unfavorable free floatation of the C terminus.
FUDAEUIGIJZUAY-UMIRZPQISA-N
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上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-12407 | FUDAEUIGIJZUAY-UMIRZPQISA-N
ZK168281 | 186371-96-0 | 1mg | 8500元 |
FUDAEUIGIJZUAY-UMIRZPQISA-N
生产厂家
186371-96-0, FUDAEUIGIJZUAY-UMIRZPQISA-N 相关搜索:
- 化合物 T13404
- 186371-96-0
- 2-Propenoic acid, 3-[1-[(1R,2E,4R)-4-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylenecyclohexylidene]ethylidene]octahydro-7a-methyl-1H-inden-1-yl]-1-hydroxy-2-penten-1-yl]cyclopropyl]-, ethyl ester, (2E)-
- ZK-168281,ZK168281
- ZK168281
- FUDAEUIGIJZUAY-UMIRZPQISA-N