LDN-192960 HYDROCHLORIDE
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- CAS号:
- 2309172-48-1
- 英文名:
- LDN-192960 (hydrochloride)
- 英文别名:
- LDN-192960 (hydrochloride);LDN192960 hydrochloride,LDN 192960 hydrochloride;3-[(2,7-Dimethoxyacridin-9-yl)thio]-1-propanamine Dihydrochloride
- 中文名:
- LDN-192960 HYDROCHLORIDE
- 中文别名:
- 化合物 T11830;3-[(2,7-二甲氧基吖啶-9-基)硫基]-1-丙胺二盐酸盐
- CBNumber:
- CB04666529
- 分子式:
- C18H21ClN2O2S
- 分子量:
- 364.89
- MOL File:
- 2309172-48-1.mol
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LDN-192960 HYDROCHLORIDE化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO:20.07(Max Conc. mg/mL);50.01(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);24.92(Max Conc. mM)-
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形态:
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A crystalline solid
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颜色:
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Light yellow to yellow
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LDN-192960 HYDROCHLORIDE性质、用途与生产工艺
LDN-192960 hydrochloride 是 Haspin 和 DYRK2 的双重抑制剂,IC50 值分别为 10 nM 和 48 nM。
IC50: 10 nM (Haspin); 48 nM (DYRK2)
LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC
50
<1 μM), including CLK1 (IC
50
=0.21 μM), DYRK1A (IC
50
= 0.10 μM), DYRK2 (IC
50
=2 nM), DYRK3 (IC
50
=19 nM) and PIM1 (IC
50
=0.72 μM).LDN-0192960 hydrochloride (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC
50
of 1.17 μM.LDN-0192960 hydrochloride (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC
50
of 0.02 μM.
LDN-192960 HYDROCHLORIDE
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-13455A | LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride | 2309172-48-1 | 5mg | 2900元 |
2024/04/30 | HY-13455A | LDN-192960 HYDROCHLORIDE LDN-192960 hydrochloride | 2309172-48-1 | 10mg | 4700元 |
LDN-192960 HYDROCHLORIDE
生产厂家
2309172-48-1, LDN-192960 HYDROCHLORIDE 相关搜索:
- 3-[(2,7-二甲氧基吖啶-9-基)硫基]-1-丙胺二盐酸盐
- 化合物 T11830
- 2309172-48-1
- 3-[(2,7-Dimethoxyacridin-9-yl)thio]-1-propanamine Dihydrochloride
- LDN192960 hydrochloride,LDN 192960 hydrochloride
- LDN-192960 (hydrochloride)