两性霉素B杂质D:1S-氧-甲基-两性霉素B
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- CAS号:
- 136135-57-4
- 英文名:
- Amphotericin X1 (13-O-Methyl Amphotericin B)
- 英文别名:
- Amphotericin X1;Amphotericin B Impurity D;Amphotericin B Impurity 16;Amphotericin B EP Impurity B;Amphotericin B, 13-O-methyl- (9CI);Amphotericin X1 (13-0-MethylAmphotericin B);Amphotericin X1 (13-O-Methyl Amphotericin B);b . a mph ote ri c i n X1 (13-O-me th yl-a mph ote ri c i n b ),;Amphotericin B Impurity 2 (Amphotericin X1)(13-O-Methyl Amphotericin B);Amphotericin B Impurity 2 (Amphotericin B EP Impurity B)(Amphotericin X1)(13-O-Methyl Amphotericin B)
- 中文名:
- 两性霉素B杂质D:1S-氧-甲基-两性霉素B
- 中文别名:
- 两性霉素 X1;两性霉素B杂质 D;化合物 T10311;13-O-甲基 两性霉素 B;两性霉素 B EP 杂质 B;两性霉素X1(13-O-甲基两性霉素B);AMPHOTERICIN B EP杂质 B;两性霉素B杂质D:1S-氧-甲基-两性霉素B;两性霉素B杂质D:1S-氧-甲基-两性霉素B;两性霉素 B杂质2 (两性霉素 X1)(13-O-甲基 两性霉素 B)
- CBNumber:
- CB04819790
- 分子式:
- C48H75NO17
- 分子量:
- 938.12
- MOL File:
- 136135-57-4.mol
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两性霉素B杂质D:1S-氧-甲基-两性霉素B化学性质
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熔点:
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>111°C (dec.)
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沸点:
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1121.2±65.0 °C(Predicted)
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密度:
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1.31±0.1 g/cm3(Predicted)
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储存条件:
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Amber Vial, Hygroscopic, -20°C Freezer, Under inert atmosphere
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溶解度:
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DMSO (Slightly), Methanol (Slightly), Water (Slightly)
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酸度系数(pKa):
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3.68±0.70(Predicted)
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形态:
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Solid
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颜色:
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Light Yellow to Dark Yellow
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稳定性:
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Hygroscopic, Light Sensitive
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两性霉素B杂质D:1S-氧-甲基-两性霉素B性质、用途与生产工艺
Amphotericin X1 是一种 Amphotericin B 的 13-O-甲基衍生物,具有良好的抗真菌活性。Amphotericin X1 抑制白色念珠菌 33/079,副念珠菌 937A,新型隐球菌 451,黑曲霉 57A 和烟曲霉的 MIC 值分别为1 μg/mL,8 μg/mL,1 μg/mL,2 μg/mL 和 2 μg/mL。
MIC: 1 μg/mL (
Candida albicans
33/079), 8 μg/mL (
C.parapsilosis
937A), 1 μg/mL (
Cryptococcus neoformans
451), 2 μg/mL (
Aspergillus niger
57A) and 2 μg/mL (
A.fumigatus
)
Amphotericin X1 (compound 4) shows interesting antifungal activity combined with a pronounced reduction in haemolytic activity (EH
50
of 42 μg/mL) against mammalianerythrocytes in vitro.
两性霉素B杂质D:1S-氧-甲基-两性霉素B
上下游产品信息
上游原料
下游产品
两性霉素B杂质D:1S-氧-甲基-两性霉素B
生产厂家
136135-57-4, 两性霉素B杂质D:1S-氧-甲基-两性霉素B 相关搜索:
- 杂质对照品
- 两性霉素X1(13-O-甲基两性霉素B)
- 两性霉素 B杂质2 (两性霉素 X1)(13-O-甲基 两性霉素 B)
- 两性霉素B杂质 D
- 13-O-甲基 两性霉素 B
- 化合物 T10311
- 两性霉素 B EP 杂质 B
- 两性霉素 X1
- 两性霉素B杂质D:1S-氧-甲基-两性霉素B
- AMPHOTERICIN B EP杂质 B
- 两性霉素B杂质D:1S-氧-甲基-两性霉素B
- 136135-57-4
- Amphotericin X1 (13-0-MethylAmphotericin B)
- Amphotericin B Impurity 2 (Amphotericin B EP Impurity B)(Amphotericin X1)(13-O-Methyl Amphotericin B)
- Amphotericin B Impurity D
- b . a mph ote ri c i n X1 (13-O-me th yl-a mph ote ri c i n b ),
- Amphotericin B Impurity 2 (Amphotericin X1)(13-O-Methyl Amphotericin B)
- Amphotericin B Impurity 16
- Amphotericin B, 13-O-methyl- (9CI)
- Amphotericin X1
- Amphotericin B EP Impurity B
- Amphotericin B Impurit D:13-O-Methylamphotericin B(14,39-Dioxabicyclo[33.3.1]nonatriacontane Amphotericin B derivative)
- Amphotericin X1 (13-O-Methyl Amphotericin B)