盐酸KHS101
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- CAS号:
- 1784282-12-7
- 英文名:
- KHS101 hydrochloride
- 英文别名:
- KHS101 hydrochloride;KHS 101,inhibit,Fibroblast growth factor receptor,Inhibitor,FGFR,KHS101,KHS-101 hydrochloride,KHS101 hydrochloride,KHS-101
- 中文名:
- 盐酸KHS101
- 中文别名:
- 盐酸KHS101
- CBNumber:
- CB04844961
- 分子式:
- C18H22ClN5S
- 分子量:
- 375.92
- MOL File:
- 1784282-12-7.mol
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盐酸KHS101化学性质
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溶解度:
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Soluble to 50 mM in DMSO and to 50 mM in ethanol
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形态:
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Solid
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颜色:
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White to off-white
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盐酸KHS101性质、用途与生产工艺
KHS101是TACC3的小分子抑制剂,TACC3是中心体微管动态网络中的关键组分。
KHS101 increases neuronal differentiation of adherently cultured rat NPCs in a dose-dependent fashion (EC
50
~1 μM). KHS101-induced neuron formation (40-60% TuJ1+ cells at 1.5–5 μM KHS101) is also observed under neurosphere-forming conditions in secondary neurospheres derived from both the hippocampus and the subventricular zone (SVZ) of adult rats. Moreover, hippocampal NPCs treated with KHS101 and cultured adherently on microelectrode arrays for 12 d exhibit neuronal morphologies as well as spontaneous spiking activity, hence indicating the presence of functional, maturing neurons. KHS101 markedly attenuates tumor cell growth as compared to the cells treated with the vehicle [dimethyl sulfoxide (DMSO)]. TACC3 is a known target of KHS101 in rodent neural progenitor cells. KHS101 has been shown to cause cellular destabilization of TACC3, hence reducing endogenous TACC3 protein levels over time .
Tumor cell proliferation is markedly reduced in KHS101-treated tumors (about twofold). KHS101-treated tumors show signs of elevated cell death (reduced cellularity/increased pyknosis) compared with tumors treated with vehicle control. KHS101 treatment markedly reduces both frontal-to-caudal tumor expansion and corpus callosum invasion of vimentin-positive GBM1 cells. It is also found that the survival of animals carrying GBMX1 tumors (established 2 or 6 weeks before treatment) is markedly increased by the KHS101 treatment regimen for 10 weeks. None of the mice have to be removed from the study because of adverse side effects of the treatment. An additional experiment using a continuous KHS101 treatment regimen until the experimental endpoints also shows a marked increase in the survival of GBMX1-bearing animals. Histological endpoint analysis of KHS101- and vehicle-treated animals confirms a significantly decreased tumor size in KHS101-treated mice.
盐酸KHS101
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-10996A | KHS101 hydrochloride | | 1 mg | 386元 |
2024/08/19 | HY-10996A | 盐酸KHS101 KHS101 hydrochloride | 1784282-12-7 | 5mg | 850元 |
1784282-12-7, 盐酸KHS101 相关搜索:
- 药靶配体
- 标准品
- 盐酸KHS101
- 1784282-12-7
- KHS 101,inhibit,Fibroblast growth factor receptor,Inhibitor,FGFR,KHS101,KHS-101 hydrochloride,KHS101 hydrochloride,KHS-101
- KHS101 hydrochloride