AR-A 2
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- CAS号:
- 220051-79-6
- 英文名:
- AR-A 2
- 英文别名:
- AR-A 2;AR-A 000002;ARA 2,AR A 2;Benzamide, 4-(4-morpholinyl)-N-[(2R)-1,2,3,4-tetrahydro-5-methyl-8-(4-methyl-1-piperazinyl)-2-naphthalenyl]-
- 中文名:
- AR-A 2
- 中文别名:
- 化合物 T10360
- CBNumber:
- CB05821323
- 分子式:
- C27H36N4O2
- 分子量:
- 448.6
- MOL File:
- 220051-79-6.mol
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AR-A 2化学性质
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沸点:
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697.1±55.0 °C(Predicted)
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密度:
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1.22±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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15.50±0.20(Predicted)
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AR-A 2性质、用途与生产工艺
AR-A 2 是一种选择性的 5-HT1B receptor 拮抗剂，对豚鼠皮层 5HT1B/1D 受体有很高的亲和性，Ki 值为 0.24 nM，对豚鼠 5-HT1B 受体的 Ki 值为 0.47 nM，EC50 值为 4.5 nM，对豚鼠 5-HT1D 受体的 Ki 值为 5 nM；AR-A 2 可用于抑郁症和焦虑症的研究。
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5-HT
1B/D
Receptor
20 nM (Ki)
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5-HT
2A
Receptor
339 nM (Ki)
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5-HT
1A
Receptor
3070 nM (Ki)
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AR-A 2 (AR-A000002) is a selective 5-HT
1B
receptor antagonist, with high affinity to guinea pig cortex 5HT
1B/1D
and recombinant guinea pig 5-HT
1B
receptors (K
i
=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT
1D
receptors (K
i
, 5 nM), and shows an EC
50
of 4.5 nM for the guinea pig 5-HT
1B
receptor. AR-A 2 also binds to the rat cortical 5HT
1B/1D
receptor (K
i
, 20 nM), rat cortex 5-HT
2A
receptor (K
i
, 339 nM), rat hippocampus 5-HT
1A
receptor (K
i
, 3070 nM). In addition, AR-A 2 also exhibits affinity for dopamine D2 (K
i
, 330 nM) and α1-adrenoceptors (K
i
, 490 nM).
AR-A 2
上下游产品信息
上游原料
下游产品
220051-79-6, AR-A 2 相关搜索:
- 化合物 T10360
- 220051-79-6
- ARA 2,AR A 2
- AR-A 2
- AR-A 000002
- Benzamide, 4-(4-morpholinyl)-N-[(2R)-1,2,3,4-tetrahydro-5-methyl-8-(4-methyl-1-piperazinyl)-2-naphthalenyl]-