2',5'-DIDEOXYADENOSINE
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- CAS号:
- 6698-26-6
- 英文名:
- 2',5'-DIDEOXYADENOSINE
- 英文别名:
- NSC 95943;2',5'-DD-ADO;2',5'-DIDEOXYADENOSINE;2',5'-Dideoxyadenosine;Adenosine, 2',5'-dideoxy-;2',5'-Dideoxyadenosine >=95% (HPLC), solid;2,5-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem;5-(6-AMINOPURIN-9-YL)-2-METHYLTETRAHYDROFURAN-3-OL;(2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-Methyltetrahydrofuran-3-ol;NSC 95943 2',5'-DIDEOXYADENOSINE
- 中文名:
- 2',5'-DIDEOXYADENOSINE
- 中文别名:
- 2',5'-双脱氧腺苷;2',5'-二脱氧腺苷;2',5'-二脱氧腺苷;化合物2',5'-DIDEOXYADENOSINE;(2R,3S,5R)-5-(6-氨基-9H-嘌呤-9-基)-2-甲基四氢呋喃-3-醇
- CBNumber:
- CB0688918
- 分子式:
- C10H13N5O2
- 分子量:
- 235.24
- MOL File:
- 6698-26-6.mol
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2',5'-DIDEOXYADENOSINE化学性质
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沸点:
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547.0±60.0 °C(Predicted)
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密度:
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1.77±0.1 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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DMSO: soluble
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形态:
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solid
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酸度系数(pKa):
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14.06±0.60(Predicted)
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颜色:
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white
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2',5'-DIDEOXYADENOSINE性质、用途与生产工艺
2',5'-Dideoxyadenosine 是一种有效且非竞争性的腺苷酸环化酶 (adenylyl cyclase) 抑制剂，可以有效结合 P 位点，IC50 为 3 µM。2',5'-Dideoxyadenosine 是核苷类似物，在心脏中发挥强大的抗肾上腺素 (antiadrenergic) 作用。
IC50: 3 µM (adenylyl cyclase)
2',5'-Dideoxyadenosine (10 μM, 30 min) reduces cAMP production and blocks the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
2',5'-Dideoxyadenosine (10 μM, 30 min) blocks CCh-induced increase of phosphorylation of Akt and attenuates CCh-induced phosphorylation of Ser2448.
2',5'-Dideoxyadenosine (20-150 mM), like adenosine, dependently and reversibly inhibits the positive inotropic and chronotropic effect of beta-adrenergic stimulation with isoproterenol (8-54 pmol) up to 70% and 50%, respectively.
Western Blot Analysis
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Cell Line:
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Primary hippocampal neurons
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Concentration:
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10 μM
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Incubation Time:
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30 min
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Result:
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Reduced cAMP production and blocked the phosphorylation of GluA1 at Ser845 induced by carbachol (CCh).
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2',5'-Dideoxyadenosine (0.1 mg/kg; IP; 15 min pre-treated) fully inhibits the diuretic, natriuretic and K
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and Cl
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sparing effect of Fr•EtOAc in rats.
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Animal Model:
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Male Wistar rats (3-4 months old)
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Dosage:
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0.1 mg/kg
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Administration:
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IP; 15 min pre-treated
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Result:
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Fully inhibited the diuretic, natriuretic and K
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and Cl
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sparing effect of Fr•EtOAc in rats.
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2',5'-DIDEOXYADENOSINE
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-135878 | 2',5'-Dideoxyadenosine | | 1 mg | 431元 |
| 2024/04/30 | HY-135878 | 2',5'-DIDEOXYADENOSINE
2',5'-Dideoxyadenosine | 6698-26-6 | 5mg | 950元 |
2',5'-DIDEOXYADENOSINE
生产厂家
6698-26-6, 2',5'-DIDEOXYADENOSINE 相关搜索:
- Enzyme Inhibitors by Enzyme
- Cyclic Nucleotide Metabolism
- A to
- Adenylyl Cyclase Inhibitors
- Adenylate cyclaseG Proteins and Cyclic Nucleotides
- 化学试剂
- Cell Signaling and Neuroscience
- Cyclic Nucleotide Metabolism
- G Proteins and Cyclic Nucleotides
- Adenylyl Cyclase Inhibitors
- BioChemical
- Cell Biology
- C10H13N5O2
- 2',5'-二脱氧腺苷
- (2R,3S,5R)-5-(6-氨基-9H-嘌呤-9-基)-2-甲基四氢呋喃-3-醇
- 化合物2',5'-DIDEOXYADENOSINE
- 2',5'-双脱氧腺苷
- 2',5'-二脱氧腺苷
- 6698-26-6
- 2',5'-Dideoxyadenosine
- P-site,Adrenergic Receptor,2',5'Dideoxyadenosine,Adenylyl cyclase,cyclase,Beta Receptor,analog,heart,adenylyl,antiadrenergic,Inhibitor,Adenylate Cyclase,inhibit,nucleoside,2',5' Dideoxyadenosine,2',5'-Dideoxyadenosine
- Adenosine, 2',5'-dideoxy-
- 2,5-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem
- phosphoric acid [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl [hydroxy(phosphonooxy)phosphoryl] [(2R,3S,4R,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl] ester
- 2',5'-Dideoxyadenosine >=95% (HPLC), solid
- NSC 95943 2',5'-DIDEOXYADENOSINE
- NSC 95943
- (2R,3S,5R)-5-(6-aMino-9H-purin-9-yl)-2-Methyltetrahydrofuran-3-ol
- 5-(6-AMINOPURIN-9-YL)-2-METHYLTETRAHYDROFURAN-3-OL
- 2',5'-DD-ADO
- 2',5'-DIDEOXYADENOSINE