氨甲叶酸7-羟基代谢物
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- CAS号:
- 5939-37-7
- 英文名:
- 7-HYDROXY METHOTREXATE
- 英文别名:
- 7-OH-MTX;NSC380963;NSC 380962;NSC 380963;NSC-380963;ylamino)benzoyl)-;7-HYDROXY METHOTREXATE;7-HYDROXY METHOXTREXATE;Methotrexate Impurity 28;L-(+)-7-hydroxyamethopterin
- 中文名:
- 氨甲叶酸7-羟基代谢物
- 中文别名:
- 7-羟氨甲喋呤;7-羟甲基蝶酸;甲氨蝶呤杂质28;7-羟基甲氨蝶呤;氨甲叶酸7-羟基代谢物;(S)-2-(4-(((2,4-二氨基-7-氧代-7,8-二氢蝶呤-6-基)甲基)(甲基)氨基)苯甲酰胺基)戊二酸
- CBNumber:
- CB0773414
- 分子式:
- C20H22N8O6
- 分子量:
- 470.44
- MOL File:
- 5939-37-7.mol
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氨甲叶酸7-羟基代谢物化学性质
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熔点:
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230°C dec.
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沸点:
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571.95°C (rough estimate)
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密度:
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1.4416 (rough estimate)
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折射率:
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1.6910 (estimate)
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储存条件:
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−20°C
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溶解度:
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DMSO: slightly soluble,Ethanol: slightly soluble
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形态:
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A solid
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酸度系数(pKa):
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3.48±0.10(Predicted)
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稳定性:
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Hygroscopic
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CAS 数据库:
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5939-37-7
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氨甲叶酸7-羟基代谢物性质、用途与生产工艺
7-Hydroxymethotrexate 是 Methotrexate (MTX; HY-14519) 的主要代谢产物。Methotrexate 是一种抗代谢和抗叶酸剂,可以抑制二氢叶酸还原酶,从而防止叶酸转化为四氢叶酸,并抑制 DNA 合成。
7-Hydroxymethotrexate (7-OHMTX) has the affinity of DHFR markedly lower (>100-fold) than for Methotrexate (MTX) .
7-Hydroxymethotrexate (4 mg/kg; IV) has a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min•mg.
Animal Model:
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Male Wistar rats (270-440 g)
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Dosage:
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4 mg/kg (Pharmacokinetic Analysis)
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Administration:
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IV
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Result:
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Had a terminal half-life of 97.2 min and a total clearance value of 9.6 mL/min•mg.
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氨甲叶酸7-羟基代谢物
上下游产品信息
上游原料
下游产品
5939-37-7, 氨甲叶酸7-羟基代谢物 相关搜索:
- Pharmaceuticals
- Metabolites
- Intermediates & Fine Chemicals
- Various Metabolites and Impurities
- 标准品
- 抑制剂
- C20H22N8O6
- 769-49-9
- (S)-2-(4-(((2,4-二氨基-7-氧代-7,8-二氢蝶呤-6-基)甲基)(甲基)氨基)苯甲酰胺基)戊二酸
- 甲氨蝶呤杂质28
- 7-羟甲基蝶酸
- 7-羟基甲氨蝶呤
- 7-羟氨甲喋呤
- 氨甲叶酸7-羟基代谢物
- 5939-37-7
- NSC 380963|||NSC-380963|||NSC380962|||NSC380963|||NSC 380962|||NSC-380962
- (S)-2-(4-(((2,4-Diamino-7-oxo-7,8-dihydropteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid
- (4-(((2,4-diamino-7-oxo-7,8-dihydropteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamic acid
- NSC-380963
- NSC380963
- NSC 380963
- Methotrexate Impurity 28
- L-Glutamic acid, N-[4-[[(2,4-diamino-7,8-dihydro-7-oxo-6-pteridinyl)methyl]methylamino]benzoyl]-
- 7-Hydroxy Methotrexate Trisodium Salt
- (S)-2-(4-(((2,4-diamino-7-hydroxypteridin-6-yl)methyl)(methyl)amino)benzamido)pentanedioic acid
- 7-Hydroxy Amethopterin, 4-Amino-7-hydroxy-10-methylpteroylglutamic Acid
- L-(+)-7-hydroxyamethopterin
- ylamino)benzoyl)-
- l-glutamicacid,n-(4-(((2,4-diamino-1,7-dihydro-7-oxo-6-pteridinyl)methyl)meth
- glutamicacid,n-(p-(((2,4-diamino-7-hydroxy-6-pteridinyl)methyl)methylamino)
- Methotrexate 7-Hydroxy Metabolite
- NSC 380962
- N-[4-[[(2,4-DiaMino-7,8-dihydro-7-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid
- N-[4-[[(2,4-Diamino-7-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid
- N-[4-[[(2,4-Diamino-7-hydroxypteridin-6-yl)methyl](methyl)amino]benzoyl]-L-glutamic acid
- 7-OH-MTX
- 7-HYDROXY METHOXTREXATE
- 7-HYDROXY METHOTREXATE