ANATABINE DICITRATE
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- CAS号:
- 英文名:
- Anatabine dicitrate
- 英文别名:
- Anatabine dicitrate
- 中文名:
- ANATABINE DICITRATE
- 中文别名:
- 柠檬酸新烟草碱;新烟草碱柠檬酸盐;ANATABINE DICITRATE
- CBNumber:
- CB08021508
- 分子式:
- 分子量:
- 0
- MOL File:
- Mol file
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ANATABINE DICITRATE化学性质
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形态:
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Solid
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颜色:
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White to off-white
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ANATABINE DICITRATE性质、用途与生产工艺
Anatabine dicitrate 是一种烟草生物碱，可以穿过血脑屏障。Anatabine dicitrate 是一种有效的 α4β2 nAChR 激动剂。Anatabine dicitrate 通过阻止淀粉样蛋白前体蛋白的 β 裂解，抑制 NF-κB 激活，并降低淀粉样 β (Aβ) 的产生。Anatabine dicitrate 具有抗炎作用，可用于神经退行性疾病的研究。
NF-κB
Amyloid-β (Aβ)
α4β2 nAChR
Anatabine (600 μg/mL; 24 hours; SHSY-5Y cells) treatment shows an inhibition of p65 NF-κB phosphorylation.
Anatabine (500-1000μg/mL; 30 minutes; SHSY-5Y cells) treatment fully prevents the increase in BACE-1 mRNA levels induced by TNF-α. After 24 hours, Anatabine treatment shows a dose-dependent inhibition of BACE-1 protein levels.
Anatabine dose dependently inhibits Aβ
1-40
and Aβ
1-42
with an approximate half maximal inhibitory concentration of 640 μg/mL for both Aβ
1-40
and Aβ
1-42
in 7W CHO cells. Anatabine inhibits sAPPβ secretion without impacting sAPPα suggesting that Anatabine is preventing the β-cleavage of amyloid precursor protein (APP).
Western Blot Analysis
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Cell Line:
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SHSY-5Y cells
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Concentration:
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600 μg/mL
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Incubation Time:
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24 hours
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Result:
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An inhibition of p65 NF-κB phosphorylation was observed.
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RT-PCR
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Cell Line:
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SHSY-5Y cells
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Concentration:
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500 μg/mL, 1000 μg/mL
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Incubation Time:
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30 minutes
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Result:
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Fully prevented the increase in BACE-1 mRNA levels induced by TNF-α.
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Anatabine (0.5-2 mg/kg; intraperitoneal injection; daily; for 4 days; transgenic mouse) treatment significantly lowers brain soluble Aβ
1-40
and Aβ
1-42
levels in a transgenic mouse model of Alzheimer's disease.
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Animal Model:
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Transgenic mice overexpressing the human APP695sw mutation and the presenilin-1 mutation M146L (Tg PS1/APPsw) (50 week-old)
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Dosage:
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0.5 mg/kg, 2 mg/kg
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Administration:
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Intraperitoneal injection; daily; for 4 days
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Result:
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Significantly lowered brain soluble Aβ
1-40
and Aβ
1-42
levels in a transgenic mouse model of Alzheimer's disease.
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ANATABINE DICITRATE
上下游产品信息
上游原料
下游产品
ANATABINE DICITRATE 试剂级价格
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/08/19 | HY-19918A | Anatabine dicitrate | | 1 mg | 1136元 |
| 2024/08/19 | HY-19918A | ANATABINE DICITRATE
Anatabine dicitrate | | 5mg | 2500元 |
ANATABINE DICITRATE 相关搜索:
- 新烟草碱柠檬酸盐
- 柠檬酸新烟草碱
- ANATABINE DICITRATE
- Anatabine dicitrate