KELATORPHAN
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- CAS号:
- 92175-57-0
- 英文名:
- Kelatorphan
- 英文别名:
- Kelatorphan;OJCFZTVYDSKXNM-GXSJLCMTSA-N;N-[(R)-4-(Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-alanine;L-Alanine, N-[(2R)-4-(hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-;(2S)-2-[[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]amino]propanoic acid
- 中文名:
- KELATORPHAN
- 中文别名:
- 化合物 T15652;化合物 KELATORPHAN
- CBNumber:
- CB11178992
- 分子式:
- C14H18N2O5
- 分子量:
- 294.3
- MOL File:
- 92175-57-0.mol
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KELATORPHAN化学性质
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密度:
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1.301±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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3.58±0.10(Predicted)
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颜色:
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White to off-white
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KELATORPHAN性质、用途与生产工艺
Kelatorphan 是脑啡肽降解酶 (enkephalin degrading enzymes) 的全抑制剂。
Enkephalin degrading enzyme.
The administration of Kelatorphan alone (50 μg) could result in a strong increase of intact [
3
H]enkephalin content corresponding to 80±11% of total recovered radioactivity. In normal awake rats, Kelatorphan (10±20 mg/kg i.v.) increases minute-volume. The increase in ventilation is due to a dose-dependent increase in breathing frequency. In arthritic rats Kelatorphan (20 mg/kg i.v.) increases ventilation and there is no significant difference between arthritic and non-arthritic rats. In pentobarbital-anesthetized rats, a slight (116%) but significant increase of respiration is also produced by Kelatorphan (20 mg/kg, n=6) 10±15 min after administration. The effects of Kelatorphan are not antagonized by a pretreatment with a small dose of naloxone (0.2 mg/kg i.v., 15 min before Kelatorphan), but a larger dose (1 mg/kg) significantly antagonized Kelatorphan (20 mg/kg) at 5 and 10 min in awake rats.
KELATORPHAN
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-10827 | Kelatorphan | | 1 mg | 2800元 |
2024/08/19 | HY-10827 | Kelatorphan | | 5 mg | 8200元 |
92175-57-0, KELATORPHAN 相关搜索:
- 抑制剂
- 化合物 KELATORPHAN
- 化合物 T15652
- 92175-57-0
- L-Alanine, N-[(2R)-4-(hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-
- (2S)-2-[[(2R)-2-benzyl-4-(hydroxyamino)-4-oxobutanoyl]amino]propanoic acid
- OJCFZTVYDSKXNM-GXSJLCMTSA-N
- N-[(R)-4-(Hydroxyamino)-1,4-dioxo-2-(phenylmethyl)butyl]-L-alanine
- Kelatorphan