125068-54-4
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- CAS号:
- 125068-54-4
- 英文名:
- NSP 805
- 英文别名:
- NSP 805;Inhibitor,NSP805,inhibit,NSP-805,NSP 805,Phosphodiesterase (PDE);5-Methyl-6-(4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one;3(2H)-Pyridazinone, 4,5-dihydro-5-methyl-6-[4-[(2-methyl-3-oxo-1-cyclopenten-1-yl)amino]phenyl]-
- 中文名:
- 125068-54-4
- 中文别名:
- 化合物NSP-805;5-甲基-6-(4-((2-甲基-3-氧代环戊-1-烯-1-基)氨基)苯基)-4,5-二氢哒嗪-3(2H)-酮
- CBNumber:
- CB11366706
- 分子式:
- C17H19N3O2
- 分子量:
- 297.35
- MOL File:
- 125068-54-4.mol
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125068-54-4化学性质
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密度:
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1.30±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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13.84±0.60(Predicted)
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颜色:
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Light yellow to yellow
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125068-54-4性质、用途与生产工艺
NSP-805 是一种有效的,选择性的 phosphodiesterase 3 (PDE3) 抑制剂,为一种强心剂,具有舒张血管的作用。
In isolated guinea pig left atria, NSP-805 shows positive inotropic EC
50
value in order of potency of 0.18 μM. The in vitro positive inotropic effects of NSP-805 is accompanied by increases in tissue cyclic AMP and abolished by carbachol.
In anesthetized dogs, intravenous (i.v.) injection of NSP-805 produces dose-dependent increases in left ventricular VVdp/dtmax and decreases in aortic blood pressure (ABP) with relatively small increases in heart rate (HR). The ED
50
value for LVdP/dtmax of NSP-805 is 12 μg/kg. When the drugs is administered intraduodenally to anesthetized dogs, the ED
50
value for LVdP/dtmax of NSP-805, is approximately 10 μg/kg. In the propranolol-induced heart failure model, NSP-805 completely improves the hemodynamic state of heart failure to normal levels. NSP-805(100 μg/kg) reduces systemic blood pressure significantly, but the increase of chorio-retinal blood flow is less than that at the low dose of NSP-805 (40 μg/kg) in rabbit eyes.
125068-54-4
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更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-19102 | NSP-805 | | 1 mg | 800元 |
2024/08/19 | HY-19102 | 125068-54-4 NSP-805 | 125068-54-4 | 5mg | 2000元 |
125068-54-4, 125068-54-4 相关搜索:
- 5-甲基-6-(4-((2-甲基-3-氧代环戊-1-烯-1-基)氨基)苯基)-4,5-二氢哒嗪-3(2H)-酮
- 化合物NSP-805
- 125068-54-4
- 5-Methyl-6-(4-((2-methyl-3-oxocyclopent-1-en-1-yl)amino)phenyl)-4,5-dihydropyridazin-3(2H)-one
- Inhibitor,NSP805,inhibit,NSP-805,NSP 805,Phosphodiesterase (PDE)
- 3(2H)-Pyridazinone, 4,5-dihydro-5-methyl-6-[4-[(2-methyl-3-oxo-1-cyclopenten-1-yl)amino]phenyl]-
- NSP 805