洋橄榄叶素
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- CAS号:
- 37318-06-2
- 英文名:
- elaiophylin
- 英文别名:
- EfoMycin E;Salbomycin;Elaiophilin;elaiophylin;GopalaMicin;EfoMycine E;Azalomycin B;Olive leaf hormone;Elaiophylin (Azalomycin B);255-E, 5001B, 56-62, 846 I, SNA 4606-3, AzaloMycin B, GopalaMicin, SalboMycin
- 中文名:
- 洋橄榄叶素
- 中文别名:
- 阿扎霉素;洋橄榄叶素
- CBNumber:
- CB11393845
- 分子式:
- C54H88O18
- 分子量:
- 1025.27
- MOL File:
- 37318-06-2.mol
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洋橄榄叶素化学性质
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熔点:
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179-182℃
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沸点:
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1080.5±65.0 °C(Predicted)
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密度:
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1.25
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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酸度系数(pKa):
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12.18±0.70(Predicted)
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形态:
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White to off-white solid.
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颜色:
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White to Off-White
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洋橄榄叶素性质、用途与生产工艺
盐霉素(Salinomycin)是由白色链霉菌经发酵产生的聚醚类动物专用抗生素，具有防治动物球虫病和促进畜禽生长发育的功能，被广泛地用于国内外的畜牧业中。但是，在盐霉素产品中，如果发酵工艺或菌种发生变化，将会有洋橄榄叶素的伴生，当含量超出一定限度，将对饲养对象产生不良反应，一定程度上会影响盐霉素的使用效果。
洋橄榄叶素是一种微生物代谢物，可用作对照品。
Elaiophylin (Azalomycin B; Gopalamicin; Efomycin E) 是一种自噬 (autophagy) 抑制剂，在卵巢癌细胞中作为单一药剂发挥抗肿瘤活性。
Elaiophylin-mediated autophagy inhibition and lysosomal dysfunction affect ovarian cancer cell survival during hypoxia. Exposure to Elaiophylin (0.025-0.5 μM; 24 hours) causes a significant increase in ovarian cancer SKOV3 cell death in hypoxia conditions.
In both the SKOV3 and A2780 cell lines, Elaiophylin (0.25, 0.5, 0.75 μM; 24 hours) treatment leads to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner.
Cell Viability Assay
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Cell Line:
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Ovarian cancer SKOV3 cells.
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Concentration:
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0.025, 0.05, 0.1, 0.2, 0.5 μM
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Incubation Time:
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24 hours
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Result:
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Caused a significant increase in ovarian cancer SKOV3 cells death in hypoxia conditions.
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Western Blot Analysis
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Cell Line:
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Ovarian cancer SKOV3 cells; A2780 cells
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Concentration:
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0.25, 0.5, 0.75 μM
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Incubation Time:
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24 hours
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Result:
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Treatment led to significant activation of cleaved CASP9/caspase-9 and PARP1 and downregulation of BIRC5/survivin in a concentration-dependent manner.
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Treatment with 2 mg/kg Elaiophylin (given i.p. every 2 days for 21 days; in BALB/C athymic mice) significantly suppresses ovarian cancer SKOV3 cells growth compared with DMSO treatment, resulting in a 72% decrease in the average daily tumor growth rate compared with DMSO treatment .
Lower doses of Elaiophylin as a single agent exert significant antitumor activity, while higher doses lead to intestinal toxicity. Administration of a lower dose (2 mg/kg) of Elaiophylin as a single agent achieves a significant antitumor effect without toxicity in an orthotopic ovarian cancer model with metastasis. Toxic reactions are observed only in the 8 mg/kg group.
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Animal Model:
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4-wk-old BALB/C athymic mice with ovarian cancer SKOV3 cells
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Dosage:
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1 or 2 mg/kg
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Administration:
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Given i.p. every 2 days for 21 days
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Result:
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Treatment with 2 mg/kg significantly suppressed ovarian cancer SKOV3 cells growth compared with DMSO treatment.
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洋橄榄叶素
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/11/08 | HY-15184 | 洋橄榄叶素
Elaiophylin | 37318-06-2 | 1mg | 3920元 |
| 2024/08/19 | HY-15184 | 洋橄榄叶素
Elaiophylin | 37318-06-2 | 5mg | 9760元 |
37318-06-2, 洋橄榄叶素 相关搜索:
- 抑制剂
- 中药对照品
- 微生物代谢物
- C54H88O18
- 阿扎霉素
- 洋橄榄叶素
- 37318-06-2
- Olive leaf hormone
- Elaiophilin
- Salbomycin
- Elaiophylin (Azalomycin B)
- 255-E, 5001B, 56-62, 846 I, SNA 4606-3, AzaloMycin B, GopalaMicin, SalboMycin
- GopalaMicin
- EfoMycine E
- EfoMycin E
- Azalomycin B
- elaiophylin