TNP 351
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- CAS号:
- 125991-51-7
- 英文名:
- TNP 351
- 英文别名:
- TNP 351;N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid;L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-
- 中文名:
- TNP 351
- 中文别名:
- 化合物 T26283
- CBNumber:
- CB11399317
- 分子式:
- C21H24N6O5
- 分子量:
- 440.45
- MOL File:
- 125991-51-7.mol
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TNP 351性质、用途与生产工艺
TNP-351 是一种抗叶酸剂。TNP-351 是一种二氢叶酸还原酶 (DHFR) 抑制剂，在体内外对白血病和实体瘤细胞均具有有效的抗肿瘤活性。
TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED
50
values of 0.79 and 2.7 nM, respectively.
The ED
50
values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively.
Cell Viability Assay
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Cell Line:
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L1210 and CCRF-CEM cells
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Concentration:
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0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells
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Incubation Time:
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48 hours for L1210 cells; 72 hours for CCRF-CEM cells
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Result:
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The ED
50
values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively.
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TNP 351
上下游产品信息
上游原料
下游产品
125991-51-7, TNP 351 相关搜索:
- 化合物 T26283
- 125991-51-7
- L-Glutamic acid, N-[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-
- N-[4-[3-(2,4-Diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]-L-glutamic acid
- TNP 351