1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲
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- CAS号:
- 792173-99-0
- 英文名:
- N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- 英文别名:
- CS-1891;SB334867/SB-334867;SB334867A free base;SB-334867,CID 6604926;SB-334867 (free base);SB-334867 >=98% (HPLC);N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA;Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-;N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- 中文名:
- 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲
- 中文别名:
- SB 334867游离;化合物SB-334867;SB 334867,OX 1受体拮抗剂;N-(2-甲基-6-苯并恶唑基)-N'-1,5-二氮杂萘-4-基脲;1-(2-甲基苯并[D]恶唑-6-基)-3-(1,5-萘啶-4-基)脲;1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲
- CBNumber:
- CB11519689
- 分子式:
- C17H13N5O2
- 分子量:
- 319.32
- MOL File:
- 792173-99-0.mol
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1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲化学性质
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沸点:
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450.5±30.0 °C(Predicted)
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密度:
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1.472
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储存条件:
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room temp
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溶解度:
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insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO
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形态:
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powder
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酸度系数(pKa):
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10.21±0.43(Predicted)
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颜色:
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white to beige
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CAS 数据库:
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792173-99-0
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1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲性质、用途与生产工艺
SB-334867 是一种选择性 orexin-1 (OX1) receptor 拮抗剂。
In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response.
In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. SB-334867 also inhibits the development of morphine analgesic tolerance in rats.
SB-334867 是一种选择性 orexin-1 (OX1) receptor 拮抗剂。
在CHO-OX1细胞,SB-334867抑制orexin-A (10 nM)和orexin-B (100 nM)诱导的钙响应,pKB 分别为7.27 和7.23,对UTP (3 microM)诱导的钙反应没有作用。
在雄性和雌性大鼠体内,SB-334867 (30 mg/kg, i.p.)显著减少天然和orexin-A诱导的食物摄入。 在大鼠体内,867 (2 mg/kg, i.v.)阻断抗精神病药对多巴胺神经元活性的作用。在大鼠体内,SB-334867也会抑制吗啡镇痛耐受性的发展。
1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/04/30 | HY-10895A | 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲 SB-334867 free base | 792173-99-0 | 5mg | 700元 |
2024/04/30 | HY-10895A | 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲 SB-334867 free base | 792173-99-0 | 10mM * 1mLin DMSO | 770元 |
1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲
生产厂家
792173-99-0, 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲 相关搜索:
- Inhibitors
- 合成有机化合物配体
- 小分子抑制剂,天然产物
- SB 334867,OX 1受体拮抗剂
- 1-(2-甲基苯并[D]恶唑-6-基)-3-(1,5-萘啶-4-基)脲
- SB 334867游离
- 化合物SB-334867
- N-(2-甲基-6-苯并恶唑基)-N'-1,5-二氮杂萘-4-基脲
- 1-(2-甲基苯并[D]噁唑-6-基)-3-(1,5-萘啶-4-基)脲
- 792173-99-0
- N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA
- CHO,BEC,ethanol,intake,SB334867 free base,sucrose,Hypocretin Receptor,locomotor,cell,activity,SB334867A,Orexin Receptor (OX Receptor),SB 334867 free base,HCRT Receptor,inhibit,Inhibitor
- N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA USP/EP/BP
- SB-334867 >=98% (HPLC)
- Urea, N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl-
- SB334867A free base
- CS-1891
- SB334867/SB-334867
- SB-334867,CID 6604926
- 1-(2-METHYL-1,3-BENZOXAZOL-6-YL)-3-(1,5-NAPHTHYRIDIN-4-YL)UREA
- N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl
- N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-ylurea SB334867
- 1-(2-Methylbenzo[d]oxazol-5-yl)-3-(1,5-naphthyridin-4-yl)urea
- SB-334867 (free base)
- 1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea
- N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA