17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮
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- CAS号:
- 32694-37-4
- 英文名:
- 17β-Hydroxy-5α-androstane-3,11-dione
- 英文别名:
- 11-KDHT;11-Ketodihydrotestosterone;5α-dihydro-11-keto Testosterone;5α-ANDROSTAN-17β-OL-3, 11-DIONE;5α-dihydro-11-keto Testosterone;17β-Hydroxy-5α-androstane-3,11-dione;17β-Hydroxy-5α-androstane-3,11-dione;5.alpha.-dihydro-11-keto Testosterone;5alpha-Androstane-3,11-dione-17beta-ol;17beta-Hydroxy-5alpha-androstane-3,11-dione
- 中文名:
- 17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮
- 中文别名:
- 睾酮杂质3;11-酮二氢睾酮;化合物 T10041;17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮
- CBNumber:
- CB12259629
- 分子式:
- C19H28O3
- 分子量:
- 304.43
- MOL File:
- 32694-37-4.mol
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17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮化学性质
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沸点:
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453.4±45.0 °C(Predicted)
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密度:
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1.152±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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crystalline solid
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酸度系数(pKa):
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14.82±0.60(Predicted)
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颜色:
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White to off-white
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17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮性质、用途与生产工艺
11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) 是一种内源性类固醇，是 11β-羟基雄烯二酮的代谢产物。11-Ketodihydrotestosterone 是一种活性雄激素，也是一种有效的雄激素受体 (AR) 激动剂，对人 AR 的 Ki 为 20.4 nM，EC50 为 1.35 nM。11-Ketodihydrotestosterone 在雄激素依赖性前列腺癌细胞中诱导基因调节，蛋白质表达和细胞生长。
Ki: 20.4 nM (Human androgen receptor)
EC50: 1.35 nM (Human androgen receptor)
11-Ketodihydrotestosterone (11-KDHT; 1-10 nM; 24 hours; LNCaP and VCaP cells) treatment induces significant cell proliferation.
11-Ketodihydrotestosterone (11-KDHT; 0.1-10 nM; 7-10 days; LNCaP and VCaP cells) treatment results in the significant upregulation of
KLK3
,
TMPRSS2
and
FKBP5
in both LNCaP and VCaP cells, with the exception of
KLK3
at 1 nM in LNCaP cells.
In PNT2 cells, only 20% of 11β-hydroxyandrostenedione (11OHA4) and 11β-hydroxytestosterone (11OHT) are metabolised with the former yielding 11keto-androstenedione (11KA4), 11-Ketodihydrotestosterone (11-KDHT) and 11β-hydroxy-5α-androstanedione (11OH-5αDIONE) and the latter yielding 11OHA4, 11KT and 11-Ketodihydrotestosterone with downstream products <0.03 μM.
In prostate cancer tissue, C11-oxy C19 metabolites at significantly higher levels than the C19 steroids are detected, with unconjugated 11-Ketodihydrotestosterone, 11KT and 11OHA4 levels ranging between 13 and 37.5 ng/g. Analyses of total steroid levels in plasma show significant levels of 11OHA4 (≈230-440 nM), 11KT (≈250-390 nM) and 11-Ketodihydrotestosterone (≈19 nM).
Cell Proliferation Assay
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Cell Line:
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LNCaP and VCaP cells
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Concentration:
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0.1 nM, 1 nM or 10 nM
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Incubation Time:
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7 days (LNCaP cells) or 10 days (VCaP cells)
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Result:
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Induced significant cell proliferation.
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RT-PCR
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Cell Line:
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LNCaP and VCaP cells
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Concentration:
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1 nM, 10 nM
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Incubation Time:
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24 hours
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Result:
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Resulted in the significant upregulation of
KLK3
,
TMPRSS2
and
FKBP5
in both LNCaP (Fig 3) and VCaP (Fig 4) cells.
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17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/08/19 | HY-135794 | 11-Ketodihydrotestosterone | | 1 mg | 1590元 |
| 2024/08/19 | HY-135794 | 17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮
11-Ketodihydrotestosterone | 32694-37-4 | 5mg | 3500元 |
17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮
生产厂家
32694-37-4, 17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮 相关搜索:
- 睾酮杂质3
- 化合物 T10041
- 11-酮二氢睾酮
- 17BETA-羟基-5ALPHA-雄甾烷-3,11-二酮
- 32694-37-4
- 5α-ANDROSTAN-17β-OL-3, 11-DIONE
- 5α-dihydro-11-keto Testosterone
- 17β-Hydroxy-5α-androstane-3,11-dione
- Androstane-3,11-dione, 17-hydroxy-, (5α,17β)-
- 11-KDHT
- 5α-dihydro-11-keto Testosterone
- 5.alpha.-dihydro-11-keto Testosterone
- 17beta-Hydroxy-5alpha-androstane-3,11-dione
- 11-Ketodihydrotestosterone
- 5alpha-Androstane-3,11-dione-17beta-ol
- 17β-Hydroxy-5α-androstane-3,11-dione