UK 383367
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- CAS号:
- 348622-88-8
- 英文名:
- 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
- 英文别名:
- CS-483;UK 383367;UK-383367 (UK 383367);UK-383367
DISCONTINUED;3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide;3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide;(R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide;(βR)-3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide;5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide;1,2,4-Oxadiazole-5-propanamide, 3-(aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-, (βR)-
- 中文名:
- UK 383367
- 中文别名:
- UK 383367,BMP-1(PCP)抑制剂;(R)-5-(6-环己基-1-(羟基氨基)-1-氧代己-3-基)-1,2,4-恶二唑-3-甲酰胺;5-[(1R)-4-环己基-1-[2-(羟基氨基)-2-氧代乙基]丁基]-1,2,4-恶二唑-3-甲酰胺
- CBNumber:
- CB12518889
- 分子式:
- C15H24N4O4
- 分子量:
- 324.38
- MOL File:
- 348622-88-8.mol
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UK 383367化学性质
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熔点:
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136-138℃
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密度:
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1.233
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储存条件:
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Sealed in dry,Room Temperature
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溶解度:
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DMSO: >30mg/mL
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形态:
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powder
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酸度系数(pKa):
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9.03±0.20(Predicted)
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颜色:
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white to off-white
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旋光性 (optical activity):
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[α]/D ≥15°, c = 0.5 in methanol
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UK 383367性质、用途与生产工艺
UK 383367是procollagen C-proteinase(前胶原C端蛋白酶)抑制剂,IC50为44 nM,对MMPs具有优异的选择性。
Target | Value |
Procollagen C proteinase
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44 nM
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UK-383367有效穿透人体皮肤。UK-383367抑制胶原沉积, IC50为~2 μM。UK-383367对所有PDE-4亚型具有适度的亲和力,作用于PDE-4a, PDE-4b, PDE-4c 和 PDE-4d, IC50分别为1.8 μM, 1.5 μM, 2.4 μM 和 0.9 μM。UK-383367是一种弱酸性化合物,具有亲脂性。
UK-383367作用于大鼠,狗和人的血浆蛋白结合值分别为95%,93%和94%。UK-383367在大鼠血浆中温育,半衰期为49分钟。UK-383367按2 mg/kg剂量单独静脉给药处理大鼠,血浆清除率为157 mL min
UK 383367
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-13102 | UK 383367 UK-383367 | 348622-88-8 | 5mg | 1200元 |
2024/08/19 | HY-13102 | UK-383367 | | 10 mM * 1 mLin DMSO | 1320元 |
348622-88-8, UK 383367 相关搜索:
- Inhibitors
- 抑制剂
- 药靶配体
- 活性小分子库
- 代谢
- 小分子抑制剂,天然产物
- (R)-5-(6-环己基-1-(羟基氨基)-1-氧代己-3-基)-1,2,4-恶二唑-3-甲酰胺
- UK 383367,BMP-1(PCP)抑制剂
- 5-[(1R)-4-环己基-1-[2-(羟基氨基)-2-氧代乙基]丁基]-1,2,4-恶二唑-3-甲酰胺
- 348622-88-8
- 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
- (R)-5-(6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl)-1,2,4-oxadiazole-3-carboxamide
- UK-383367
DISCONTINUED
- 3-(Aminocarbonyl)-beta-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide USP/EP/BP
- UK-383367 (UK 383367)
- CS-483
- 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
- 5-[(1R)-4-Cyclohexyl-1-[2-(hydroxyamino)-2-oxoethyl]butyl]-1,2,4-oxadiazole-3-carboxamide
- UK 383367
- (βR)-3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
- 1,2,4-Oxadiazole-5-propanamide, 3-(aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-, (βR)-