网站主页 >> CAS数据库列表 >> 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
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- CAS号:
- 257879-35-9
- 英文名:
- PKCβ Inhibitor
- 英文别名:
- KUN79359;PKCβ Inhibitor;PKCβ Inhibitor;PKCβ inhibitor 1;PKCβ inhibitor 1;3-anilino-4-[1-(3-imidazol-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[1-[3-(1H-imidazol-1-yl)propyl]-1H-indol-3-yl]-4-(phenylamino)-;PKCβ inhibitor 1,GSK3β,Inhibitor,tumor,PKCβ inhibitor1,proliferation,BCBL-1,mTOR,selective,inhibit,PKC,phosphorylation,cell,Apoptosis,PKCβ inhibitor-1,Protein kinase C,2F7,ATP-competitive
- 中文名:
- 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
- 中文别名:
- 化合物PKCΒ INHIBITOR 1;3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
- CBNumber:
- CB12628270
- 分子式:
- C24H21N5O2
- 分子量:
- 411.46
- MOL File:
- 257879-35-9.mol
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3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮化学性质
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溶解度:
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DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 0.25 mg/ml
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形态:
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A solid
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3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮性质、用途与生产工艺
PKCβ inhibitor 1 是有效的，ATP 竞争性和选择性 PKCβ 抑制剂，对人 PKCβ1 和 PKCβ2 的 IC50 分别为 21 和 5 nM。与 PKCβ2 相比，PKCβ inhibitor 1 对其他 PKC 同工酶 (PKCα、PKCγ 和 PKCε) 具有 60 倍以上的选择性。
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human PKCβ1
21 nM (IC
50
)
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human PKCβ2
5 nM (IC
50
)
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PKCα
331 nM (IC
50
)
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PKCβ inhibitor 1 (0-30 μM; 48 hours) suppresses tumor cell proliferation in a time- and dose-dependent manner.
PKCβ inhibitor 1 (14 μM; 2-48 hours) induces apoptosis in 2F7 cells.
PKCβ inhibitor 1 (15 μM; 2-48 hours) inhibits cell cycle progression in 2F7 and BCBL-1 cells.
PKCβ (15 or 14 μM, respectively; 2-48 hours) inhibitor 1 reduces the expression of phospho-PKCβ in BCBL-1 and 2F7 cells.
PKCβ inhibitor 1(0-48 hours) suppresses GSK3β, mTOR, and S6 phosphorylation.
Cell Proliferation Assay
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Cell Line:
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2F7, BCBL-1 cells
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Concentration:
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0, 5, 10, 20, and 30 μM
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Incubation Time:
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48 hours
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Result:
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A dose-dependent reduction in viability of the 2F7 and BCBL-1 cells starting at 5 μM and increasing with elevated inhibitor concentration.
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Apoptosis Analysis
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Cell Line:
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2F7 cells
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Concentration:
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14 μM
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Incubation Time:
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2-48 hours
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Result:
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Apoptotic induction in 2.1% of the 2F7 cells above background after 2 hours of treatment, increasing through 48 hours of treatment.
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Cell Cycle Analysis
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Cell Line:
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BCBL-1 Cells
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Concentration:
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15 μM (the IC
50
)
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Incubation Time:
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2-48 hours
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Result:
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Inhibits cell cycle progression in 2F7 and BCBL-1 cells.
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Western Blot Analysis
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Cell Line:
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BCBL-1 and 2F7 cell lines
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Concentration:
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15 or 14 μM (at the IC
50
respectively)
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Incubation Time:
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2-48 hours
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Result:
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The expression of phospho-PKCβ in BCBL-1 and 2F7 cells reduced.
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3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-13335 | 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
PKCβ inhibitor 1 | 257879-35-9 | 500μg | 1100元 |
| 2024/04/30 | HY-13335 | 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
PKCβ inhibitor 1 | 257879-35-9 | 1mg | 1800元 |
3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
生产厂家
257879-35-9, 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮 相关搜索:
- 对照品
- 化合物PKCΒ INHIBITOR 1
- 3-[1-[3-(1H-咪唑-1-基)丙基]-1H-吲哚-3-基]-4-(苯氨基)-1H-吡咯-2,5-二酮
- 257879-35-9
- PKCβ Inhibitor
- PKCβ inhibitor 1,GSK3β,Inhibitor,tumor,PKCβ inhibitor1,proliferation,BCBL-1,mTOR,selective,inhibit,PKC,phosphorylation,cell,Apoptosis,PKCβ inhibitor-1,Protein kinase C,2F7,ATP-competitive
- PKCβ inhibitor 1
- 1H-Pyrrole-2,5-dione, 3-[1-[3-(1H-imidazol-1-yl)propyl]-1H-indol-3-yl]-4-(phenylamino)-
- KUN79359
- PKCβ inhibitor 1
- 3-anilino-4-[1-(3-imidazol-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione
- PKCβ Inhibitor