泊沙康唑主环

泊沙康唑主环性质、用途与生产工艺

概述

泊沙康唑主环(posaconazole)是伊曲康唑的衍生物，于2006年在FDA上市的第二代三唑类抗真菌药物，商品名为NOXAFIL，原研厂家为先灵葆雅。

制备

先灵葆雅于1995年在US5661151A公开了泊沙康唑主环的合成路线，它以2'-氯-2,4-二氟苯乙酮为起始原料，通过Wittig反应，构型的翻转，最终得到终产品。

泊沙康唑主环 上下游产品信息

上游原料

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泊沙康唑主环 生产厂家

175712-02-4, 泊沙康唑主环 相关搜索:

• 主打产品
• 系列1
• 杂质对照品
• 抗菌
• 对照品-杂质对照品
• 中间体
• 医药中间体
• C20H18ClF2N3O4S
• 5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-甲基)四氢呋喃-3-甲基]对…
• 泊沙康唑主环M10A
• ((3S,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氢呋喃-3-基)甲基4-氯苯磺酸酯(POS85-V)
• 泊沙康唑主环2(CBSCL)
• 4-氯苯磺酸5-(2,4-二氟苯基)-5-[1,2,4]三唑-1-基甲基四氢呋喃-3-基甲酯
• ((3S,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氢呋喃-3-基)甲基4-氯苯磺酸酯
• ((3S,5R)-5-((1H-1,2,4-三唑-1-基)甲基)-5-(2,4-二氟苯基)四氢呋喃-3-基)4-氯苯磺酸甲酯
• B泊沙康唑杂质14
• 泊沙康唑杂质106
• 泊沙康唑主环
• 5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-甲基)四氢呋喃-3-甲基]对氯苯磺酸酯,泊沙康唑中间体
• 泊沙康唑主环(对氯保护基)
• 泊沙康唑氯代
• 泊沙康唑主环(含对氯苯磺酸保护基)
• 5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-甲基)四氢呋喃-3-甲基]对氯苯磺酸酯,泊沙康唑中间体 500G
• 泊沙对氯主环
• (3S-顺式)-4-氯苯磺酸[5-(2,4-二氟苯基)四氢-5-(1H-1,2,4-三唑-1-基甲基)-3-呋喃基]甲基酯
• 泊沙康唑中间体9
• 5-(2,4-二氟苯基)-5-(1,2,4-三唑-1-甲基)四氢呋喃-3-甲基]对氯苯磺酸酯
• 175712-02-4
• N-(2-((4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)amino)ethyl)-N-(4-(1-((2S,3S)-2-hydroxypentan-3-yl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)phenyl)formamide
• "D-THREO-PENTITOL 2 5-ANHYDRO-4-[[[(4-CHLOROPHENYL)SULFONYL]OXY]METHYL]-1 3 4-TRIDEOXY-2-C-(2 4-DIFLUOROPHENYL)-1-(1H-1 2 4-TRIA
• Posaconazole Intermediate 9
• 4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3
• [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)...
• Posaconazole POA
• Posaconazole Impurity 106
• D-threo-Pentitol, 2,5-anhydro-4-[[[(4-chlorophenyl)sulfonyl]oxy]methyl]-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-
• [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methyl 4-chlorobenzenesulfonate
• EOS-60774
• 4-difluoro-phenyl)-5-[1
• 4-Chloro-benzenesulfonic acid 5-(2
• 4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl esterChemicalBook
• (3S,5R)-5-(2,4-difluoro-phenyl)-5-1,2,4triazol-1-ylmethyl-tetrahydro-furan-3-ylmethyl 4-chlorobenzenesulfote
• ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl4-chlorobenzenesulfonate
• [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetra hydrofuran-3-yl]methyl 4-chlorobenzenesulfonate
• [(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)tetrahydrofuran-3-yl]methyl 4-chlorobenzenesulfonate 4-Chloro-benzenesulfonic acid
• 2,5-Anhydro-4-[[[(4-chlorophenyl)sulfonyl]oxy]methyl]-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol
• (3S-cis)-4-Chlorobenzenesulfonic acid [5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methyl ester
• 4-Chloro-benzenesulfonic acid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester