ChemicalBook
English   Japanese   Germany   Korea

GNE-617 (hydrochloride)

GNE-617 (hydrochloride), 2070014-99-0, 结构式
GNE-617 (hydrochloride)
CAS号:
2070014-99-0
英文名:
GNE-617 (hydrochloride)
英文别名:
GNE-617 (hydrochloride)
中文名:
GNE-617 (hydrochloride)
中文别名:
NAMPT抑制剂;化合物 GNE-617 HYDROCHLORIDE
CBNumber:
CB12677081
分子式:
C21H16ClF2N3O3S
分子量:
463.88
MOL File:
2070014-99-0.mol

GNE-617 (hydrochloride)化学性质

形态:
Solid
颜色:
White to off-white
安全信息

GNE-617 (hydrochloride)性质、用途与生产工艺

生物活性

GNE-617 hydrochloride 是一种特异性的 NAMPT 抑制剂,抑制 NAMPT 活性,IC50 为 5 nM。

靶点

IC50: 5 nM (NAMPT)

体外研究

The activity ofGNE-617 hydrochloride is evaluated on a panel 53 non-small cell lung cancer (NSCLC) cell lines in the presence or absence of 10 μM nicotinic acid. GNE-617 inhibits NAMPT IC50 of 18.9 nM in A549 cell.The majority of cell lines exhibit a steep dose response to GNE-617 when evaluated by decrease in ATP or total nucleic acid, and the cytotoxicity is completely rescued by simultaneous addition of nicotinic acid. The majority of the cell lines tested have IC 50 values below 100 nM, with approximately half with IC 50 values less than 10 nM. Eighteen cell lines are not rescued with nicotinic acid, and these non-rescuable cell lines tended to have lower IC 50 values (P=0.008, Fisher exact test, IC 50 <10 nM vs. ≥10 nM).

体内研究

In rats, GNE-617 hydrochloride (administered QD) and GNE-875 (administered BID) are associated with more severe retinal toxicity at similar exposures and dosing duration compared with GMX-1778 (administered BID). The mouse efficacy studies using GNE-617, GNE-618, and GMX-1778 are designed to assess efficacy and opportunistically used to assess retinal toxicity in mice. NAMPTi retinal toxicity is observed with GNE-617 and GMX-1778; however, the different study durations between GNE-617 and GMX-1778 do not allow for direct comparison of retinal toxicity.

GNE-617 (hydrochloride) 上下游产品信息

上游原料

下游产品

GNE-617 (hydrochloride) 试剂级价格

更新日期产品编号产品名称CAS编号包装价格
2024/04/30HY-15766AGNE-617 (hydrochloride)
GNE-617 hydrochloride
2070014-99-02mg550元
2024/04/30HY-15766AGNE-617 (hydrochloride)
GNE-617 hydrochloride
2070014-99-05mg900元

GNE-617 (hydrochloride) 生产厂家

全球有 15家供应商   GNE-617 (hydrochloride)国内生产厂家
供应商联系电话电子邮件国家产品数优势度
上海皓元医药股份有限公司 021-58950125 info@chemexpress.com 中国 7553 61
上海楼岚生物科技有限公司 021-52996696,15000506266 15000506266 中国 4197 55
广州市齐云生物技术有限公司 020-61288194 61288195 505721671@qq.com 中国 3868 58
台州市科瑞生物技术有限公司 0576-88813233 13396860566 sales@pharm-intermediates.com 中国 1998 58
InvivoChem +1-708-310-1919 +1-13798911105 sales@invivochem.cn 美国 6393 58
ChemeGen 中国 18818260767 sales@chemegen.com 中国 11289 58
上海泽叶生物科技有限公司 021-61998551 13122364865 sale1@shzysw.net 中国 9771 58
InvivoChem中国 13549236410 sales@invivochem.cn 中国 6749 58
TargetMol中国(陶术生物) 4008200310 marketing@tsbiochem.com 中国 24017 58
銳迪國際科技有限公司 18024082417 market@ubiochem.com 中国 9155 58
Aladdin Scientific +1-+1(833)-552-7181 sales@aladdinsci.com 美国 52927 58
 

2070014-99-0, GNE-617 (hydrochloride) 相关搜索:

  • API
  • 细胞生物学试剂
  • 化合物 GNE-617 HYDROCHLORIDE
  • NAMPT抑制剂
  • 2070014-99-0
  • GNE-617 (hydrochloride)
Copyright 2016 © ChemicalBook. All rights reserved