OPC-14523盐酸盐
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- CAS号:
- 145969-31-9
- 英文名:
- Opc-14523 monohcl
- 英文别名:
- Opc-14523 monohcl;OPC-14523 hydrochloride;1-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-methoxy-3,4-dihydroquinolin-2-one
- 中文名:
- OPC-14523盐酸盐
- 中文别名:
- OPC-14523盐酸盐;化合物 OPC-14523 HYDROCHLORIDE
- CBNumber:
- CB13112619
- 分子式:
- C23H29Cl2N3O2
- 分子量:
- 450.4
- MOL File:
- 145969-31-9.mol
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OPC-14523盐酸盐化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 83.33 mg/mL (185.01 mM)
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形态:
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Solid
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颜色:
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White to off-white
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OPC-14523盐酸盐性质、用途与生产工艺
OPC-14523 hydrochloride 是一种具有口服活性的 sigma 和 5-HT1A 受体激动剂，对 sigma 受体 (σ1/2 IC50=47/56 nM)、5-HT1A 受体 (IC50=2.3 nM) 和 5-HT 转运体 (IC50=80 nM) 具有高度亲和力。OPC-14523 hydrochloride 显示抗抑郁药样活性。
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5-HT
1A
Receptor
2.3 nM (IC
50
)
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sigma 1
47 nM (IC
50
)
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sigma 2
56 mM (IC
50
)
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OPC-14523 hydrochloride inhibits the in vitro reuptake of 3 H-5-HT (IC
50
=27 nM), but it shows very weak inhibitory activity on
3
H-NE and
3
H-DA reuptake.
OPC-14523 hydrochloride (0.3-100 mg/kg; p.o.; daily for 0, 2, 4, 7 days) produces a marked antidepressant-like effect in the forced swimming test (FST) with rats and mice without affecting the general locomotor activity.
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Animal Model:
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Wistar strain of rats (140-245 g)
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Dosage:
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0.3-100 mg/kg
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Administration:
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P.o.; daily for 0, 2, 4, 7 days
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Result:
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A single doses of 1 mg/kg and higher of OPC-14523 reduced immobility time in the FST with an ED
50
value of 27 mg/kg. The ED
50
value for OPC-14523 on day 7 was 18 mg/kg.
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Animal Model:
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ICR strain of mice (25-45 g)
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Dosage:
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0.3-100 mg/kg
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Administration:
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P.o.; daily for 0, 2, 4, 7 days
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Result:
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A single oral dose of OPC-14523 produced a marked reduction in immobility time during the FST at oral doses of 1 mg/kg and higher, with an ED
50
value of 20 mg/kg. The potency of OPC-14523 in decreasing immobility time was greater after treatment for seven consecutive days, producing an ED50 value of 2 mg/kg.
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OPC-14523盐酸盐
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-116594A | OPC-14523 hydrochloride | | 1 mg | 1590元 |
| 2024/04/30 | HY-116594A | OPC-14523盐酸盐
OPC-14523 hydrochloride | 145969-31-9 | 5mg | 3500元 |
145969-31-9, OPC-14523盐酸盐 相关搜索:
- C23H29Cl2N3O2
- 化合物 OPC-14523 HYDROCHLORIDE
- OPC-14523盐酸盐
- 145969-31-9
- OPC-14523 hydrochloride
- 1-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-methoxy-3,4-dihydroquinolin-2-one
- Opc-14523 monohcl