1873376-49-8
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- CAS号:
- 1873376-49-8
- 英文名:
- CXCR2-IN-1
- 英文别名:
- CXCR2-IN-1;CXCR2 inhibitor 1;CXCR-2-IN-1,CXCR2 IN 1,CXCR2IN1;N-(2-Chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea;Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-
- 中文名:
- 1873376-49-8
- 中文别名:
- 化合物 T10905;化合物CXCR2-IN-1
- CBNumber:
- CB13171690
- 分子式:
- C19H20Cl2FN3O4S
- 分子量:
- 476.35
- MOL File:
- 1873376-49-8.mol
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1873376-49-8化学性质
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沸点:
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538.1±50.0 °C(Predicted)
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密度:
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1.528±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : 5.4 mg/mL (11.34 mM)
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形态:
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Solid
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酸度系数(pKa):
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5.02±0.10(Predicted)
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颜色:
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White to off-white
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1873376-49-8性质、用途与生产工艺
CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂，pIC50值为9.3。
CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 shows favorable central nervous system penetration property (Br/Bl>0.45).
CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis.
1873376-49-8
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101022 | CXCR2-IN-1 | | 1 mg | 500元 |
| 2024/11/08 | HY-101022 | 1873376-49-8
CXCR2-IN-1 | 1873376-49-8 | 5mg | 900元 |
1873376-49-8, 1873376-49-8 相关搜索:
- 抑制剂
- 标准品
- C19H20Cl2FN3O4S
- 化合物CXCR2-IN-1
- 化合物 T10905
- 1873376-49-8
- CXCR-2-IN-1,CXCR2 IN 1,CXCR2IN1
- N-(2-Chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]urea
- Urea, N-(2-chloro-3-fluorophenyl)-N'-[4-chloro-2-hydroxy-3-[(1-methyl-4-piperidinyl)sulfonyl]phenyl]-
- CXCR2 inhibitor 1
- CXCR2-IN-1