L-NIL
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- CAS号:
- 53774-63-3
- 英文名:
- N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE
- 英文别名:
- L NIL,LNIL;H-LYS(ACETIMIDOYL)-OH;H-LYS(1-IMINOETHYL)-OH;LYSINE(ACETIMIDOYL)-OH;Ne-Acetimidoyl-L-lysine;N-ε-Acetimidoyl-L-lysine;N-(5-Amino-5-carboxypentyl;L-Lysine, N6-(1-iMinoethyl)-;N-EPSILON-ACETIMIDOYL-L-LYSINE;N-EPSILON-ACETIMIDOYL-L-LYSIN-EPSILON
- 中文名:
- L-NIL
- 中文别名:
- 化合物 T11805;N-(5-氨基-5-羧基戊)-乙脒;L-NIL,诱导型一氧化氮合成酶 (INOS) 的抑制剂
- CBNumber:
- CB1325601
- 分子式:
- C8H17N3O2
- 分子量:
- 187.24
- MOL File:
- 53774-63-3.mol
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L-NIL化学性质
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沸点:
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335.2±52.0 °C(Predicted)
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密度:
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1.22±0.1 g/cm3(Predicted)
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储存条件:
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-15°C
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溶解度:
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Water: 50 mg/mL (267.04 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
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形态:
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Solid
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酸度系数(pKa):
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2.52±0.24(Predicted)
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颜色:
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White to off-white
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L-NIL性质、用途与生产工艺
L-NIL 是诱导型一氧化氮合成酶 (iNOS) 的抑制剂，其对 miNOS 的 IC50 值为3.3 μM。
IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase)
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC
50
values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.
L-NIL (10 and 30 mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.
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Animal Model:
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Adult male Balb/c (20-25 g).
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Dosage:
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10 and 30 mg/kg.
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Administration:
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Intraperitoneally at the end of CLP and at 6 h after sepsis induction.
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Result:
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Led to a negligible increase in plasma NGAL compared to sham mice.
Led to a significant decrease in both TLR4 and IL1βprotein contents and clusterin transcript.
Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle.
Promoted a decrease in AR protein expression, as compared with animals treated with vehicle.
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L-NIL
上下游产品信息
上游原料
下游产品
53774-63-3, L-NIL 相关搜索:
- 合成有机化合物配体
- C8H17N3O2
- L-NIL,诱导型一氧化氮合成酶 (INOS) 的抑制剂
- N-(5-氨基-5-羧基戊)-乙脒
- 化合物 T11805
- 53774-63-3
- L NIL,LNIL
- N-ε-Acetimidoyl-L-lysine
- N-(5-AMino-5-carboxypentyl)-acetaMidine, H-Lys(1-iMinoethyl)-OH, L-NIL
- L-Lysine, N6-(1-iMinoethyl)-
- Ne-Acetimidoyl-L-lysine
- N-(5-Amino-5-carboxypentyl
- LYSINE(ACETIMIDOYL)-OH
- H-LYS(ACETIMIDOYL)-OH
- H-LYS(1-IMINOETHYL)-OH
- N-EPSILON-ACETIMIDOYL-L-LYSIN-EPSILON
- N-EPSILON-ACETIMIDOYL-L-LYSINE
- N-(5-AMINO-5-CARBOXYPENTYL)-ACETAMIDINE