2035509-96-5
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- CAS号:
- 2035509-96-5
- 英文名:
- AX-15836
- 英文别名:
- AX-15836;AX-15836,Extracellular signal regulated kinases,ERK,AX 15836,inhibit,Inhibitor,AX15836;2-((2-Ethoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-11-(methylsulfonyl)-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one;5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one;6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-11-(methylsulfonyl)-
- 中文名:
- 2035509-96-5
- 中文别名:
- 化合物AX-15836;ERK5抑制剂(AX-15836);2-((2-乙氧基-4-(4-(4-甲基哌嗪-1-基)哌啶-1-羰基)苯基)氨基)-5-甲基-11-(甲基磺酰基)-5,11-二氢-6H-苯并[E]嘧啶并[5,4-B][1,4]二氮杂卓-6-酮
- CBNumber:
- CB13309532
- 分子式:
- C32H40N8O5S
- 分子量:
- 648.78
- MOL File:
- 2035509-96-5.mol
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2035509-96-5化学性质
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沸点:
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848.9±75.0 °C(Predicted)
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密度:
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1.42±0.1 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO : ≥ 101 mg/mL (155.68 mM)
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形态:
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Solid
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酸度系数(pKa):
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8.14±0.42(Predicted)
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颜色:
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Off-white to yellow
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2035509-96-5性质、用途与生产工艺
AX-15836是有效，选择性的ERK5抑制剂，IC50值为8 nM。
AX-15836 shows more than 1,000-fold selectivity for ERK5 over a panel of over 200 kinases. It also exhibits selectivity over BRD4 with a K
d
of 3,600 nM. AX15836 shows similar intracellular potency (4–9 nM) across all cells tested, including peripheral blood mononuclear cells (PBMCs), endothelial cells, and oncogenic cell lines. AX15836 was completely ineffective (EC
50
>10 μM) to suppress inflammatory cytokine response, suggesting that it was the BRD inhibition component of the compounds that mediated cytokine reduction. In HUVEC and HeLa cell types, samples treated with AX15836 shows very few genes to be differentially expressed. AX15836 could clearly inhibit the EGF-stimulated, phosphorylated form of ERK5 in HeLa cells.
2035509-96-5
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101846 | 2035509-96-5
AX-15836 | 2035509-96-5 | 5mg | 1500元 |
| 2024/11/08 | HY-101846 | 2035509-96-5
AX-15836 | 2035509-96-5 | 10mM * 1mLin DMSO | 2140元 |
2035509-96-5, 2035509-96-5 相关搜索:
- 抑制剂
- 细胞生物学试剂
- C32H40N8O5S
- 2-((2-乙氧基-4-(4-(4-甲基哌嗪-1-基)哌啶-1-羰基)苯基)氨基)-5-甲基-11-(甲基磺酰基)-5,11-二氢-6H-苯并[E]嘧啶并[5,4-B][1,4]二氮杂卓-6-酮
- 化合物AX-15836
- ERK5抑制剂(AX-15836)
- 2035509-96-5
- 2-((2-Ethoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenyl)amino)-5-methyl-11-(methylsulfonyl)-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one
- AX-15836,Extracellular signal regulated kinases,ERK,AX 15836,inhibit,Inhibitor,AX15836
- 6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5,11-dihydro-5-methyl-11-(methylsulfonyl)-
- 5,11-Dihydro-2-[[2-ethoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5-methyl,11-(methylsulfonyl)-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one
- AX-15836