FK-448 Free base
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- CAS号:
- 85858-76-0
- 英文名:
- FK-448 Free base
- 英文别名:
- FK-448 Free base;FK 448 Free base,FK448 Free base;1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-, 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester
- 中文名:
- FK-448 Free base
- 中文别名:
- 化合物 T11290;化合物 FK-448 FREE BASE
- CBNumber:
- CB13384773
- 分子式:
- C25H30N2O3
- 分子量:
- 406.52
- MOL File:
- 85858-76-0.mol
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FK-448 Free base化学性质
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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FK-448 Free base性质、用途与生产工艺
FK-448 Free base 是一种有效的，特异性的糜蛋白酶 (chymotrypsin) 抑制剂，IC50 值为 720 nM。
IC50: 720 nM (Chymotrypsin)
FK-448 Free base is an effective and specific inhibitor of chymotrypsin, with an IC
50
of 720 nM. FK-448 Free base slightly inhibits esterolysis of Trypsin and Thrombin, with IC
50
s of 780 and 35 μM, respectively, but shows no effects on esterolysis of plasmin, plasma kallikrein or pancreas kallikrein, with IC
50
s of all >1 mM. FK-448 moderately inhibits hydrolytic activities of cathepsin G with an IC
50
of 15 μM.
FK-448 (20 mg/kg, i.p.) results in a decrease in the blood glucose level, and inhibits the degradation of insulin by pancreatic enzymes in rats. FK-448 (20 mg/kg, p.o.) also decreases the blood glucose level, and increases plasma IRI level in dogs.
FK-448 Free base
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上游原料
下游产品
85858-76-0, FK-448 Free base 相关搜索:
- 抑制剂
- 化合物 FK-448 FREE BASE
- 化合物 T11290
- 85858-76-0
- FK 448 Free base,FK448 Free base
- 1-Naphthalenecarboxylic acid, 1,2,3,4-tetrahydro-, 4-[[4-(1-methylethyl)-1-piperazinyl]carbonyl]phenyl ester
- FK-448 Free base