1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
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- CAS号:
- 349093-44-3
- 英文名:
- 1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethanone
- 英文别名:
- PTGR2-IN-1;PTGR2-IN-22;PTGR2-IN-22 PTGR2-IN-1;1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethanone;PTGR2IN1,cells,inhibit,transcriptional,HEK293T,PTGR2 IN 1,PPARγ,PTGR-2-IN-1,Inhibitor
- 中文名:
- 1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
- 中文别名:
- 化合物PTGR2-IN-22;1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
- CBNumber:
- CB13845728
- 分子式:
- C19H22N2O2
- 分子量:
- 310.39018
- MOL File:
- 349093-44-3.mol
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1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 100 mg/mL (322.18 mM)
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1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮性质、用途与生产工艺
PTGR2-IN-1 是一种有效的 PTGR2 抑制剂，IC50 为 ~0.7 μM。PTGR2-IN-1 增加了转染 PTGR2 的 HEK293T 细胞 15-keto-PGE2 依赖的 PPARγ 转录活性。
A screen of structural analogs of 20 identified PTGR2-IN-1, which shows substantially increased potency (>20-fold) in assays measuring either competition of 8-labeling or 15-keto-PGE2 reductase activity (IC50 = 0.6 μM) of recombinant PTGR2, as well as an inactive control compound 23. PTGR2-IN-1 (Compound 22) blocks FFF 8 labeling of endogenous PTGR2 in HEK293T cells with good potency (complete inhibition at 5 μM and ~80% inhibition at 500 nM) and excellent selectivity.
1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/04/30 | HY-122716 | PTGR2-IN-1 | | 1 mg | 612元 |
| 2024/04/30 | HY-122716 | 1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
PTGR2-IN-1 | 349093-44-3 | 5mg | 1530元 |
1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
生产厂家
349093-44-3, 1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮 相关搜索:
- 化合物PTGR2-IN-22
- 1-(4-(2-甲氧基苯基)哌嗪-1-基)-2-苯基乙酮
- 349093-44-3
- PTGR2-IN-22 PTGR2-IN-1
- PTGR2IN1,cells,inhibit,transcriptional,HEK293T,PTGR2 IN 1,PPARγ,PTGR-2-IN-1,Inhibitor
- PTGR2-IN-1
- PTGR2-IN-22
- 1-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylethanone