1821143-79-6
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- CAS号:
- 1821143-79-6
- 英文名:
- DMU2105
- 英文别名:
- (2E)-3-(naphthalen-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one;2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)-, (2E)-
- 中文名:
- 1821143-79-6
- 中文别名:
- 化合物 T11065
- CBNumber:
- CB14796645
- 分子式:
- C18H13NO
- 分子量:
- 259.3
- MOL File:
- 1821143-79-6.mol
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1821143-79-6化学性质
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沸点:
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463.7±37.0 °C(Predicted)
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密度:
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1.194±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Solid
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酸度系数(pKa):
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2.89±0.10(Predicted)
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颜色:
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Light yellow to yellow
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1821143-79-6性质、用途与生产工艺
DMU2105 是有效的特异性细胞色素 P4501B1 (CYP1B1) 的抑制剂，其对 CYP1B1 和 CYP1A1 的 IC50 值分别为 10 nM 和 742 nM。
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CYP1B1
10 nM (IC
50
)
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CYP1A1
742 nM (IC
50
)
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DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC
50
goes down to 1 μM indicating that the cells have suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC
50
) do not show any perceptible decrease of cisplatin EC
50
(8.5 μM ± 0.9).
1821143-79-6
上下游产品信息
上游原料
下游产品
1821143-79-6, 1821143-79-6 相关搜索:
- API
- 化合物 T11065
- 1821143-79-6
- (2E)-3-(naphthalen-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one
- 2-Propen-1-one, 3-(2-naphthalenyl)-1-(3-pyridinyl)-, (2E)-