CC-90009
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- CAS号:
- 1860875-51-9
- 英文名:
- CC-90009
- 英文别名:
- CC-90009;Eragidomide;Cereblon modulator 1;Eragidomide(CC-90009);Cereblon modulator 1(CC-99);CC-90009; CC 90009; CC90009;;2-(4-Chlorophenyl)-N-[[2-(2,6-dioxo-3-piperidyl)-1-oxoisoindolin-5-yl]methyl]-2,2-difluoroacetamide;2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide;2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide;Benzeneacetamide, 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-
- 中文名:
- CC-90009
- 中文别名:
- CEREBLON MODULATOR 1;化合物CEREBLON MODULATOR 1;2-(4-氯苯基)-N-((2-(2,6-二氟哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺;2-(4-氯苯基)-N-((2-(2,6-二氧哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺;2-(4-氯苯基)-N-[[2-(2,6-二氧代-3-哌啶基)-1-氧代异吲哚啉-5-基]甲基]-2,2-二氟乙酰胺
- CBNumber:
- CB15833721
- 分子式:
- C22H18ClF2N3O4
- 分子量:
- 461.85
- MOL File:
- 1860875-51-9.mol
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CC-90009化学性质
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沸点:
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770.1±60.0 °C(Predicted)
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密度:
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1.466±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: 250 mg/mL (541.30 mM)
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形态:
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A crystalline solid
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酸度系数(pKa):
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10.66±0.40(Predicted)
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颜色:
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Off-white to light yellow
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CC-90009性质、用途与生产工艺
CRBN
PROTAC--Ligands for E3 Ligase
CC-90009与CRBN特异性结合,从而影响泛素E3 连接酶复合物的活性。
CC-90009是一种新型cereblon (CRBN) E3 连接酶调节剂,专门针对GSPT1进行蛋白酶体降解。
CC-90009与CRL4
CRBN结合选择性靶向GSPT1以进行泛素化和蛋白酶体降解。GSPT1 是一种小的 GTPase,它与翻译终止因子eRF1形成复合物以介导翻译终止。CC-90009通过促进 GSPT1 降解可快速诱导急性髓系白血病(AML)细胞凋亡。
CC-90009
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | HY-130800 | CC-90009 Eragidomide | 1860875-51-9 | 5 mg | 750元 |
2024/08/19 | HY-130800 | CC-90009 Eragidomide | 1860875-51-9 | 10 mM * 1 mLin DMSO | 762元 |
1860875-51-9, CC-90009 相关搜索:
- APIS
- 天然产物
- 抑制剂
- 医药研发中间体
- C22H18ClF2N3O4
- 2-(4-氯苯基)-N-((2-(2,6-二氧哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺
- 2-(4-氯苯基)-N-[[2-(2,6-二氧代-3-哌啶基)-1-氧代异吲哚啉-5-基]甲基]-2,2-二氟乙酰胺
- 2-(4-氯苯基)-N-((2-(2,6-二氟哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺
- 化合物CEREBLON MODULATOR 1
- CEREBLON MODULATOR 1
- 1860875-51-9
- 2-(4-Chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
- 2-(4-chlorophenyl)-N-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]methyl]-2,2-difluoroacetamide
- 2-(4-Chlorophenyl)-N-[[2-(2,6-dioxo-3-piperidyl)-1-oxoisoindolin-5-yl]methyl]-2,2-difluoroacetamide
- proteasome-mediated,CRBN,degradation,Eragidomide,CC-90009,Molecular Glues,E3 ligase-recruiting Moiety,IKZF3,IRF4,IKZF1,c-myc,Inhibitor,anti-cancer,Ligands for E3 Ligase,inhibit,CC 90009,Apoptosis,CC90009,T-lymphocytes
- Eragidomide(CC-90009)
- Eragidomide
- Cereblon modulator 1(CC-99)
- Benzeneacetamide, 4-chloro-N-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]methyl]-α,α-difluoro-
- Cereblon modulator 1
- CC-90009; CC 90009; CC90009;
- CC-90009