Lactimidomycin
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- CAS号:
- 134869-15-1
- 英文名:
- Lactimidomycin
- 英文别名:
- Lactimidomycin;Lactimidomycin
(Bu-4146T);4-[(Z)-2-hydroxy-5-methyl-7-[(4Z,6Z,10Z)-3-methyl-12-oxo-1-oxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-enyl]piperidine-2,6-dione;2,6-Piperidinedione, 4-[(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4Z,6E,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxo-6-octen-1-yl]-
- 中文名:
- Lactimidomycin
- 中文别名:
- 化合物 T15703;4-[(Z)-2-羟基-5-甲基-7-[(4Z,6Z,10Z)-3-甲基-12-氧代-1-氧杂环十二碳-4,6,10-三烯-2-基]-4-氧代辛-6-烯基]哌啶-2,6-二酮
- CBNumber:
- CB21120392
- 分子式:
- C26H35NO6
- 分子量:
- 457.56
- MOL File:
- 134869-15-1.mol
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Lactimidomycin性质、用途与生产工艺
Lactimidomycin 是从链霉菌中分离出的含戊二酰亚胺的化合物。Lactimidomycin 是一种有效的真核翻译延伸抑制剂，对肿瘤细胞系具有有效的抗增殖作用，并选择性抑制蛋白质翻译。Lactimidomycin 抑制蛋白质合成，IC50 值为 37.82 nM。Lactimidomycin 还是登革热病毒 2 和其他 RNA 病毒的有效且无毒的抑制剂。抗癌和抗病毒活性。
Eukaryotic translation elongation
Dengue virus 2 and other RNA viruses
Lactimidomycin (0.01-100 nM; 24 hours; Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A) treatment inhibits cell growth with IC
50
concentrations in the low nanomolar range, but higher doses are necessary to inhibit growth of the non-tumorigenic breast cell line MCF10A.
Lactimidomycin induces a clear dose-responsive inhibition of DENV2 infectious particle production with an EC
90
value of 0.4 μM. No measurable decrease in cell viability was detected at concentrations up to 12.5 µM.
Lactimidomycin is a potent inhibitor of DENV2 and Lactimidomycin's inhibition of DENV2 translation leads to reduced production of newly infectious particles. Lactimidomycin may protect cells from viral cytopathic effects including apoptosis, likely through inhibition of virus protein production and replication.
Cell Proliferation Assay
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Cell Line:
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Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A
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Concentration:
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0.01-100 nM
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Incubation Time:
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24 hours
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Result:
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Inhibited cell growth with IC
50
concentrations in the low nanomolar range.
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Lactimidomycin (0.6 mg/kg; intraperitoneal injection; daily; for one month; female nude mice) treatment has an appreciable effect on tumor growth in nude mice.
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Animal Model:
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Female nude mice (6-8 week old) with MDA MB 231 cells
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Dosage:
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0.6 mg/kg
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Administration:
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Intraperitoneal injection; daily; for one month
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Result:
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Had an appreciable effect on tumor growth in vivo.
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Lactimidomycin
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/01/25 | HY-18979 | Lactimidomycin
Lactimidomycin | 134869-15-1 | 200μg | 9700元 |
134869-15-1, Lactimidomycin 相关搜索:
- 4-[(Z)-2-羟基-5-甲基-7-[(4Z,6Z,10Z)-3-甲基-12-氧代-1-氧杂环十二碳-4,6,10-三烯-2-基]-4-氧代辛-6-烯基]哌啶-2,6-二酮
- 化合物 T15703
- 134869-15-1
- 2,6-Piperidinedione, 4-[(2R,5S,6E)-2-hydroxy-5-methyl-7-[(2R,3S,4Z,6E,10E)-3-methyl-12-oxooxacyclododeca-4,6,10-trien-2-yl]-4-oxo-6-octen-1-yl]-
- 4-[(Z)-2-hydroxy-5-methyl-7-[(4Z,6Z,10Z)-3-methyl-12-oxo-1-oxacyclododeca-4,6,10-trien-2-yl]-4-oxooct-6-enyl]piperidine-2,6-dione
- Lactimidomycin
(Bu-4146T)
- Lactimidomycin