MK-447
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- CAS号:
- 58456-91-0
- 英文名:
- 2-aminomethyl-4-t-butyl-6-iodophenol
- 英文别名:
- MK-447;2-aminomethyl-4-t-butyl-6-iodophenol;2-(aminomethyl)-4-tert-butyl-6-iodophenol;6-Iodo-2-(aminomethyl)-4-tert-butylphenol;Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodo-
- 中文名:
- MK-447
- 中文别名:
- 化合物 T12063
- CBNumber:
- CB21349995
- 分子式:
- C11H16INO
- 分子量:
- 305.16
- MOL File:
- 58456-91-0.mol
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MK-447化学性质
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熔点:
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146-146.5 °C (decomp)
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沸点:
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306.9±42.0 °C(Predicted)
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密度:
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1.552±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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酸度系数(pKa):
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7.30±0.50(Predicted)
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MK-447性质、用途与生产工艺
MK-447 是一种自由基清除剂,同时为非甾体类抗炎剂,能够增强 PGH2 等其他前列腺素 (prostaglandin) 的形成。
MK-447 is a free radical scavenger, reduces the accumulation of the endoperoxide, PGG
2
and also enhances the formation of the endoperoxide, PGH
2
, and other prostaglandins. MK-447 (100 μM) increases the amounts of prostaglandin I2 (PGI2). MK-447 also accelerates endogenous PGI2 generation in the isolated rat aorta.
MK-447 (20 and 50 mg/kg, p.o.) blocks gastric acid secretion in the 4 hour pylorus ligated rats, but shows no effect on gastric secretion of pepsin. MK-447 (5, 10, 20 and 40 mg/kg, p.o.) dose-dependently decreases acid output in dogs.
MK-447
上下游产品信息
上游原料
下游产品
58456-91-0, MK-447 相关搜索:
- 化合物 T12063
- 58456-91-0
- Phenol, 2-(aminomethyl)-4-(1,1-dimethylethyl)-6-iodo-
- 2-(aminomethyl)-4-tert-butyl-6-iodophenol
- MK-447
- 6-Iodo-2-(aminomethyl)-4-tert-butylphenol
- 2-aminomethyl-4-t-butyl-6-iodophenol