EPSILON-AMANITIN
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- CAS号:
- 21705-02-2
- 英文名:
- EPSILON-AMANITIN
- 英文别名:
- EPSILON-AMANITIN;α-Amanitin, 1-L-aspartic acid-3-[(4S)-4-hydroxy-L-isoleucine]-;Cyclo[L-Asp-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-]
- 中文名:
- 中文别名:
- CBNumber:
- CB21423789
- 分子式:
- C39H53N9O14S
- 分子量:
- 903.96
- MOL File:
- 21705-02-2.mol
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EPSILON-AMANITIN化学性质
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密度:
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1.1627 (rough estimate)
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折射率:
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1.7400 (estimate)
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EPSILON-AMANITIN性质、用途与生产工艺
ε-Amanitin，从多种蘑菇中分离出的环状肽，可有效与 RNA 聚合酶 II (RNA polymerase II) 结合并抑制其活性。
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Traditional Cytotoxic Agents
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Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation.
类别
有毒物品
毒性分级
剧毒
急性毒性
腹腔-小鼠LD50:0.3 毫克/公斤; 未名-小鼠 LD50: 0.5 毫克/公斤
可燃性危险特性
可燃;燃烧产生有毒氮氧化物和硫氧化物烟雾
储运特性
库房通风低温干燥
灭火剂
干粉、泡沫、砂土、二氧化碳, 雾状水
EPSILON-AMANITIN
上下游产品信息
上游原料
下游产品
21705-02-2, EPSILON-AMANITIN 相关搜索:
- C39H53N9O14S
- 21705-02-2
- α-Amanitin, 1-L-aspartic acid-3-[(4S)-4-hydroxy-L-isoleucine]-
- Cyclo[L-Asp-L-t4Hyp-[(4S)-4-hydroxy-L-Ile-]-6-hydroxy-L-Trp2(1)-Gly-3-methyl-L-Nva-Gly-3-oxomercapto(1)-L-Ala-]
- EPSILON-AMANITIN