6-甲氧基-3-吡啶羧胺
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- CAS号:
- 7150-23-4
- 英文名:
- 6-Methoxynicotinamide
- 英文别名:
- JBSNF-000088;BUTTPARK 182\12-94;6-Methoxynicotinamide;Benzopyrene Impurity 5;JBSNF-000088
(JBSNF000088;6-methoxy-3-pyridinecarboxamide;6-METHOXYPYRIDINE-3-CARBOXAMIDE;3-PYRIDINECARBOXAMIDE, 6-METHOXY-;Inhibitor,JBSNF 000088,inhibit,6-Methoxynicotinamide,JBSNF-000088
- 中文名:
- 6-甲氧基-3-吡啶羧胺
- 中文别名:
- 6-甲氧基烟酰胺;6-甲氧基-3-吡啶羧胺;6-甲氧基-3-吡啶甲酰胺;化合物JBSNF-000088
- CBNumber:
- CB22463564
- 分子式:
- C7H8N2O2
- 分子量:
- 152.15
- MOL File:
- 7150-23-4.mol
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6-甲氧基-3-吡啶羧胺化学性质
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熔点:
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178-180°C
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沸点:
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301.6±22.0 °C(Predicted)
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密度:
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1.213±0.06 g/cm3(Predicted)
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储存条件:
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-20°C Freezer
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溶解度:
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DMSO (Slightly), Methanol (Slightly)
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形态:
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Solid
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酸度系数(pKa):
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15.17±0.50(Predicted)
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颜色:
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Off-White to Pale Beige
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InChI:
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InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10)
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InChIKey:
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KXDSMFBEVSJYRF-UHFFFAOYSA-N
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SMILES:
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C1=NC(OC)=CC=C1C(N)=O
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6-甲氧基-3-吡啶羧胺性质、用途与生产工艺
JBSNF-000088 (6-Methoxynicotinamide)是一种 烟酰胺(NA)的类似物,是 Nicotinamide N-methyltransferase (NNMT) 的有效抑制剂,对 human NNMT(hNNMT)、monkey NNMT (mkNNMT) 和 mouse NNMT (mNNMT)的IC50值为1.8 µM、2.8 µM 和 5.0 µM。
Target | Value |
hNNMT
(Cell-free assay)
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1.8 μM
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mkNNM
(Cell-free assay)
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2.8 μM
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mNNMT
(Cell-free assay)
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5.0 μM
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JBSNF-000088 (6-Methoxynicotinamide) has IC
50
values are 1.6 and 6.3 µM for U2OS or differentiated 3T3L1 cells.
JBSNF-000088 (6-Methoxynicotinamide) (50 mg/kg; oral route of administration for four weeks) shows statistically significant reduction in body weight (%) and leads to a statistically significant reduction in fed blood glucose on day 21.
JBSNF-000088 (50 mg/kg; oral gavage administration; twice daily for four weeks) leads to a statistically significant improvement in oral glucose tolerance on day 28 with glucose tolerance being normalized.
JBSNF-000088 (1 mg/kg; intravenous administration; for 4 hours) results in low plasma clearance of 21 mL/min▪kg and the volume of distribution at steady state of 0.7 L/kg, a very short plasma half-life of 0.5 hours upon intravenous administration.
JBSNF-000088 (10 mg/kg; oral gavage; for 4 hours) results in a Cmax of 3568 ng/mL with a T
max
value of 0.5 hours, indicating rapid absorption in the intestine, and half-life of 0.4 hours by oral gavage. The oral bioavailability is found to be approximately 40%.
Animal Model:
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Mice with high fat diet (HFD)-induced obesity
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Dosage:
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50 mg/kg
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Administration:
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Oral route of administration for four weeks; oral gavage administration and twice daily for four weeks
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Result:
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Showed statistically significant reduction in body weight (%) and led to a statistically significant reduction in fed blood glucose on day 21 by oral route of administration.
Led to a statistically significant improvement in oral glucose tolerance on day 28 with glucose tolerance being normalized by oral gavage administration.
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Animal Model:
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C57BL/6 mice
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Dosage:
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1 mg/kg (Intravenous administration);10 mg/kg (oral gavage)(Pharmacokinetic Study)
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Administration:
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Intravenous administration and oral gavage; for 4 hours
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Result:
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Resulted in low plasma clearance of 21 mL/min▪kg and the volume of distribution at steady state of 0.7 L/kg, a very short plasma half-life of 0.5 h upon intravenous administration.
Resulted in a Cmax of 3568 ng/mL with a T
max
value of 0.5 hours, indicating rapid absorption in the intestine, and half-life of 0.4 hours by oral gavage.
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6-甲氧基-3-吡啶羧胺
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下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/08/19 | XW02715023403 | 6-甲氧基-3-吡啶羧胺 | 7150-23-4 | 1G | 409元 |
2024/08/19 | S6779 | 6-甲氧基-3-吡啶羧胺 JBSNF-000088 | 7150-23-4 | 25mg | 470.74元 |
7150-23-4, 6-甲氧基-3-吡啶羧胺 相关搜索:
- 现货
- 减肥
- 药靶配体
- 抑制剂
- 6-甲氧基烟酰胺
- 化合物JBSNF-000088
- 6-甲氧基-3-吡啶甲酰胺
- 6-甲氧基-3-吡啶羧胺
- 7150-23-4
- Benzopyrene Impurity 5
- Inhibitor,JBSNF 000088,inhibit,6-Methoxynicotinamide,JBSNF-000088
- 6-methoxy-3-pyridinecarboxamide
- JBSNF-000088
(JBSNF000088
- JBSNF-000088
- BUTTPARK 182\12-94
- 6-METHOXYPYRIDINE-3-CARBOXAMIDE
- 3-PYRIDINECARBOXAMIDE, 6-METHOXY-
- 6-Methoxynicotinamide