Pardoprunox
|
|
|
- CAS号:
- 269718-84-5
- 英文名:
- Pardoprunox
- 英文别名:
- SLV-308;DU 126891;Pardoprunox;SLV-308; DU-126891;pardoprunox (SLV308);Pardoprunox，DU 126891;7-(4-Methyl-1-piperazinyl)-2(3H)-benzoxazolone;2(3H)-Benzoxazolone, 7-(4-methyl-1-piperazinyl)-;7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one
- 中文名:
- Pardoprunox
- 中文别名:
- 帕多芦诺
- CBNumber:
- CB22498836
- 分子式:
- C12H15N3O2
- 分子量:
- 233.27
- MOL File:
- 269718-84-5.mol
|
|
|
Pardoprunox化学性质
-
密度:
-
1.258±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
Store at -20°C
-
|
-
溶解度:
-
Soluble in DMSO
-
|
-
酸度系数(pKa):
-
9.15±0.70(Predicted)
-
|
Pardoprunox性质、用途与生产工艺
Pardoprunox (SLV-308) 是多巴胺受体 D2、D3 部分激动剂和 5-HT1A 激动剂，pEC50 分别为 8, 9.2, 6.3。
|
5-HT
1A
Receptor
6.3 (pEC
50
)
|
D
2
Receptor
8 (pEC
50
)
|
D
3
Receptor
9.2 (pEC
50
)
|
Pardoprunox (SLV-308) acts as a potent but partial D2 receptor agonist (pEC
50
= 8.0 and pA
2
=8.4) with an efficacy of 50% on forskolin stimulated cAMP accumulation. At human recombinant dopamine D3 receptors, Pardoprunox acts as a partial agonist in the induction of [(35)S]GTPgammaS binding (intrinsic activity of 67%; pEC
50
=9.2) and antagonized the dopamine induction of [(35)S]GTPgammaS binding (pA
2
=9.0). Pardoprunox acts as a full 5-HT1A receptor agonist on forskolin induced cAMP accumulation at cloned human 5-HT1A receptors but with low potency (pEC
50
=6.3).
Pardoprunox
上下游产品信息
上游原料
下游产品
269718-84-5, Pardoprunox 相关搜索:
- Inhibitors
- 抑制剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- 帕多芦诺
- 269718-84-5
- 2(3H)-Benzoxazolone, 7-(4-methyl-1-piperazinyl)-
- 7-(4-methylpiperazin-1-yl)-3H-1,3-benzoxazol-2-one
- Pardoprunox，DU 126891
- SLV-308; DU-126891
- SLV-308
- pardoprunox (SLV308)
- 7-(4-Methyl-1-piperazinyl)-2(3H)-benzoxazolone
- DU 126891
- Pardoprunox