网站主页 >> CAS数据库列表 >> 2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐
2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐
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- CAS号:
- 324523-20-8
- 英文名:
- 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride
- 英文别名:
- NPS-2143 HCL;NPS-2143 (Mono HCl);NPS2143;NPS 2143 HCL;SB-262470-A hydrochloride;NPS2143 hydrochloride, >=98%;NPS-2143/SB-262470A hydrochloride);NPS-2143 hydrochloride (SB-262470A);2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride;(R)-2-Chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride;2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1)
- 中文名:
- 2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐
- 中文别名:
- NPS2143盐酸盐;化合物NPS-2143 HCL;2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐;(R)-2-氯-6-(2-羟基-3-((2-甲基-1-(萘-2-基)丙-2-基)氨基)丙氧基)苯甲腈 盐酸盐
- CBNumber:
- CB22509916
- 分子式:
- C24H26Cl2N2O2
- 分子量:
- 445.38
- MOL File:
- 324523-20-8.mol
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2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐化学性质
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储存条件:
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2-8°C
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溶解度:
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DMSO: >10mg/mL
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形态:
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powder
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颜色:
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white to beige
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旋光性 (optical activity):
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[α]20/D +20 to +24°, c = 1.0 in methanol
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2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐性质、用途与生产工艺
NPS-2143 hydrochloride (SB-262470A hydrochloride),口服活性溶钙剂,是选择性的钙敏感受体 (CaSR) 拮抗剂。NPS-2143 hydrochloride (SB-262470A hydrochloride) 通过激活表达人 Ca2+ 受体的 HEK 293 细胞中的 Ca2+ 受体而引起的胞浆 Ca2+ 浓度增加 (IC50=43 nM)。
NPS-2143 hydrochloride (SB-262470A hydrochloride) stimulates parathyroid hormone (PTH) secretion from bovine parathyroid cells with EC
50
of 41 nM. Moreover, NPS-2143 hydrochloride also blocks the inhibitory effects of calcimimetic NPS R-467 on PTH secretion from bovine parathyroid cells and the inhibitory effects of extracellular Ca2+ on isoproterenol-stimulated increases in cyclic AMP formation.
When infused intravenously in normal rats, NPS-2143 hydrochloride (SB-262470A hydrochloride) causes a rapid and large increase in plasma levels of PTH. Ca
2+
receptor antagonists are termed calcilytics and NPS-2143 is the first substance (either atomic or molecular) shown to possess such activity.
When administered together with an antiresorptive agent (estradiol), NPS 2143 causes an increase in trabecular bone volume and bone mineral density in osteopenic rats.
2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐
上下游产品信息
上游原料
下游产品
2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐
生产厂家
324523-20-8, 2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐 相关搜索:
- 抑制剂
- C24H25ClN2O2HCl
- (R)-2-氯-6-(2-羟基-3-((2-甲基-1-(萘-2-基)丙-2-基)氨基)丙氧基)苯甲腈 盐酸盐
- 化合物NPS-2143 HCL
- NPS2143盐酸盐
- 2-氯-6-[(2R)-3-[[1,1-二甲基-2-(2-萘基)乙基]氨基]-2-羟基丙氧基]苯腈盐酸盐
- 324523-20-8
- NPS-2143/SB-262470A hydrochloride)
- NPS2143,NPS-2143,CaSR,NPS 2143 hydrochloride,Calcium-sensing receptor,inhibit,SB-262470A,Inhibitor,NPS 2143,NPS2143 hydrochloride
- (R)-2-Chloro-6-(2-hydroxy-3-((2-methyl-1-(naphthalen-2-yl)propan-2-yl)amino)propoxy)benzonitrile hydrochloride
- NPS2143;NPS 2143 HCL
- NPS-2143 hydrochloride (SB-262470A)
- NPS2143 hydrochloride, >=98%
- SB-262470-A hydrochloride
- 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]-benzonitrile hydrochloride (1:1)
- NPS-2143 (Mono HCl)
- NPS-2143 HCL
- 2-Chloro-6-[(2R)-3-[[1,1-dimethyl-2-(2-naphthalenyl)ethyl]amino]-2-hydroxypropoxy]benzonitrile hydrochloride