IDE 1
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- CAS号:
- 1160927-48-9
- 英文名:
- IDE 1
- 英文别名:
- IDE 1;IDE-1;IDE1;IDE-1;IDE1;IDE 1;IDE1,inhibit,IDE-1,IDE 1,Inhibitor;2-{(e)-[(6-carboxyhexanoyl)hydrazono]methyl}benzoic Acid;1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid;Heptanedioic acid, 1-[2-[(2-carboxyphenyl)methylene]hydrazide]
- 中文名:
- IDE 1
- 中文别名:
- 化合物IDE1
- CBNumber:
- CB22535674
- 分子式:
- C15H18N2O5
- 分子量:
- 306.31
- MOL File:
- 1160927-48-9.mol
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IDE 1化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.63(Max Conc. mM)
DMSO:28.54(Max Conc. mg/mL);93.18(Max Conc. mM)
Ethanol:0.1(Max Conc. mg/mL);0.33(Max Conc. mM)-
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形态:
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White solid.
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颜色:
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White to off-white
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IDE 1性质、用途与生产工艺
IDE1 是一种定形内胚层诱导物，可能会被用于器官移植等方面。
IDE1 enhances the definitive endoderm (DE) differentiation of human-induced pluripotent stem cells (hiPSCs) with Activin A/Wnt3a being significantly more potent in both 2D and 3D cultures compared to IDE1. IDE1 could efficiently induces DE differentiation through various protocols in vitro. Treatment of the hiPSCs-derived EBs with IDE-1 shows minor increase (p<0.01) of DE-markers cells compared to Activin A/Wnt3a treatment. IDE1 possess several advantages over other inducing factors including high permeability, influence, diversity, low cost, and easy to use and for the first time, Melton’s team showed that Activin A can be substituted by two cell-permeable small molecules, IDE1 and IDE2. IDE1 could induce phosphorylation of Smad2 after incubation for 24 h or more at levels comparable to those induced by Activin A treatment. Treatment of hiPSCs with IDE1 (2 mM) also leads to endodermal differentiation but with a significantly lower efficiency than Activin A/Wnt3a.
IDE 1
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-100533 | IDE 1
IDE1 | 1160927-48-9 | 1mg | 500元 |
| 2024/11/08 | HY-100533 | IDE 1
IDE1 | 1160927-48-9 | 10 mM * 1 mLin DMSO | 640元 |
1160927-48-9, IDE 1 相关搜索:
- 抑制剂
- 化合物IDE1
- 1160927-48-9
- IDE1,inhibit,IDE-1,IDE 1,Inhibitor
- Heptanedioic acid, 1-[2-[(2-carboxyphenyl)methylene]hydrazide]
- 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
- IDE-1;IDE1;IDE 1
- IDE-1;IDE1
- 2-{(e)-[(6-carboxyhexanoyl)hydrazono]methyl}benzoic Acid
- IDE 1