AT13148
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- CAS号:
- 1056901-62-2
- 英文名:
- AT-13148
- 英文别名:
- CS-1252;AT-13148;AT13148 HCl;AT13148, >=98%;AT-13148;AT 13148;AT-13148 USP/EP/BP;AT13148 hydrochloride;AT 13148 dihydrochloride;AT-13148; AT 13148; AT13148; AT13148 HYDROCHLORIDE; AT13148 HCL;(S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
- 中文名:
- AT13148
- 中文别名:
- 化合物AT13148;AT13148,AKT抑制剂;AGC KINASE抑制剂(AT13148);(+)-(S)-2-氨基-1-(4-氯苯基)-1-[4-(1H-吡唑-4-基)苯基]乙醇
- CBNumber:
- CB22627346
- 分子式:
- C17H16ClN3O
- 分子量:
- 313.78
- MOL File:
- 1056901-62-2.mol
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AT13148化学性质
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沸点:
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595.9±50.0 °C(Predicted)
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密度:
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1.328±0.06 g/cm3(Predicted)
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储存条件:
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Store at -20°C
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溶解度:
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Soluble in DMSO
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形态:
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Powder
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酸度系数(pKa):
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10.92±0.50(Predicted)
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颜色:
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White to off-white
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AT13148性质、用途与生产工艺
AT13148是一种口服的，ATP竞争性的，多AGC kinase抑制剂，对Akt1/2/3，p70S6K，PKA，和ROCKI/II的IC50分别为38 nM/402 nM/50 nM，8 nM，3 nM，和6 nM/4 nM。Phase 1。
AT13148, as a multi-AGC kinase inhibitor, potently inhibits proliferation with GI50 values of 1.5 to 3.8 μM across a selected panel of cancer cell lines with deregulation of PI3K-AKT-mTOR or RAS-RAF pathways. In PTEN-deficient MES-SA cells, AT13148 also inhibits AKT and p70S6K signaling.
AT13148 (50 mg/kg p.o.) markedly inhibits the activity of both AKT and p70S6K AGC kinases, and subsequently exhibits marked antitumor effects in human tumor xenografts.
AT13148是一种口服的，ATP竞争性的，多AGC kinase抑制剂，对Akt1/2/3，p70S6K，PKA，和ROCKI/II的IC50分别为38 nM/402 nM/50 nM，8 nM，3 nM，和6 nM/4 nM。Phase 1。
| Target | Value |
PKA
(Cell-free assay)
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3 nM
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ROCK2
(Cell-free assay)
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4 nM
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ROCK1
(Cell-free assay)
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6 nM
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p70S6K
(Cell-free assay)
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8 nM
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Akt1
(Cell-free assay)
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38 nM
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AT13148，作为多重AGC激酶抑制剂，有效抑制癌细胞增殖，对选定的一组PI3K-AKT-mTOR 或 RAS-RAF通路反常的癌细胞系，GI50 值为1.5到3.8 μM。在PTEN缺陷型MES-SA细胞中，AT13148也会抑制AKT 和 p70S6K信号。
在人肿瘤异种移植物中，AT13148 (50 mg/kg p.o.)显著抑制AKT 和p70S6K AGC激酶的活性，并随后表现出显著的抗肿瘤作用。
AT13148
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-16071 | AT13148 | | 1 mg | 500元 |
| 2024/04/30 | S7563 | AT13148
AT13148 | 1056901-62-2 | 5mg | 1186.89元 |
1056901-62-2, AT13148 相关搜索:
- Inhibitors
- 药靶配体
- 细胞生物学试剂
- 小分子抑制剂，天然产物
- 小分子抑制剂
- AT13148,AKT抑制剂
- 化合物AT13148
- AGC KINASE抑制剂(AT13148)
- (+)-(S)-2-氨基-1-(4-氯苯基)-1-[4-(1H-吡唑-4-基)苯基]乙醇
- 1056901-62-2
- inhibit,AT 13148,Protein kinase B,S6K,AT13148,PKB,AT-13148,ROK,Protein kinase A,Rho-associated protein kinase,Akt,PKA,Rho-associated kinase,Ribosomal S6 Kinase (RSK),Rho-kinase,ROCK,Inhibitor
- CS-1252
- AT-13148;AT 13148
- AT-13148; AT 13148; AT13148; AT13148 HYDROCHLORIDE; AT13148 HCL
- AT13148 hydrochloride
- AT13148 HCl
- AT-13148 USP/EP/BP
- Benzenemethanol, α-(aminomethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-, (αS)-
- (+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol AT13148
- (S)-1-(4-(1H-pyrazol-4-yl)phenyl)-2-amino-1-(4-chlorophenyl)ethanol
- (alphaS)-alpha-(Aminomethyl)-alpha-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)benzenemethanol
- (+)-(S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol
- AT-13148
- (1S)-2-Amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol
- AT 13148 dihydrochloride
- AT13148, >=98%